p53MutaGene: an online tool to estimate the effect of p53 mutational status on gene regulation in cancer

被引：8

作者：

Amelio, I. ^{[1
]}

Knight, R. A. ^{[1
]}

Lisitsa, A. ^{[2
]}

Melino, G. ^{[1
,3
]}

Antonov, A. V. ^{[1
]}

机构：

[1] Med Res Council Toxicol Unit, Leicester LE1 9HN, Leics, England

[2] Russian Acad Med Sci, Inst Biomed Chem, Moscow, Russia

[3] Univ Roma Tor Vergata, Dept Expt Med & Surg, I-00133 Rome, Italy

来源：

CELL DEATH & DISEASE | 2016年 / 7卷

基金：

英国医学研究理事会;

关键词：

MUTANT P53; BREAST-CANCER; SURVIVAL; GAIN; REVEALS;

D O I：

10.1038/cddis.2016.42

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

p53MutaGene is the first online tool for statistical validation of hypotheses regarding the effect of p53 mutational status on gene regulation in cancer. This tool is based on several large-scale clinical gene expression data sets and currently covers breast, colon and lung cancers. The tool detects differential co-expression patterns in expression data between p53 mutated versus p53 normal samples for the user-specified genes. Statistically significant differential co-expression for a gene pair is indicative that regulation of two genes is sensitive to the presence of p53 mutations. p53MutaGene can be used in 'single mode' where the user can test a specific pair of genes or in 'discovery mode' designed for analysis of several genes. Using several examples, we demonstrate that p53MutaGene is a useful tool for fast statistical validation in clinical data of p53-dependent gene regulation patterns.

引用

页码：e2148 / e2148

页数：6

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