Regulation of body fat mass by the gut microbiota: Possible mediation by the brain

被引：14
作者：
Schele, Erik [1 ]
Grahnemo, Louise [2 ]
Anesten, Fredrik [1 ]
Hallen, Anna [2 ,3 ]
Backhed, Fredrik [2 ,3 ]
Jansson, John-Olov [1 ]
机构：
[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol Endocrinol, S-41345 Gothenburg, Sweden
[2] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden
[3] Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, Sect Metab Receptol & Enteroendocrinol,Fac Hlth S, DK-2200 Copenhagen, Denmark
来源：
PEPTIDES | 2016年 / 77卷
基金：
瑞典研究理事会;
关键词：
Obesity; Gut microbiota; BDNF; GLP-1; CENTRAL-NERVOUS-SYSTEM; NEUROTROPHIC FACTOR BDNF; GLUCAGON-LIKE PEPTIDE-1; PROTEIN-COUPLED RECEPTOR; ANXIETY-LIKE BEHAVIOR; DIET-INDUCED OBESITY; FOOD-INTAKE; PERIPHERAL GHRELIN; ENERGY-METABOLISM; NEUROPEPTIDE-Y;
D O I：
10.1016/j.peptides.2015.03.027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New insight suggests gut microbiota as a component in energy balance. However, the underlying mechanisms by which gut microbiota can impact metabolic regulation is unclear. A recent study from our lab shows, for the first time, a link between gut microbiota and energy balance circuitries in the hypothalamus and brainstem. In this article we will review this study further. (C) 2015 Published by Elsevier Inc.
引用
收藏
页码：54 / 59
页数：6
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