Recent advances in on-site mass spectrometry analysis for clinical applications

被引：50

作者：

Zhou, Xiaoyu ^{[1
]}

Zhang, Wenpeng ^{[1
]}

Ouyang, Zheng ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Precis Instrument, State Key Lab Precis Measurement Technol & Instru, Beijing 100084, Peoples R China

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2022年 / 149卷

基金：

国家重点研发计划;

关键词：

Ambient ionization; Direct sampling; Point-of-care testing; Clinical diagnostics; Miniature mass spectrometry; UNSATURATED FATTY-ACIDS; PAPER-SPRAY; AMBIENT IONIZATION; ION-TRAP; RAPID DETECTION; OPEN-AIR; MINIATURE; EXTRACTION; DRUGS; BIOANALYSIS;

D O I：

10.1016/j.trac.2022.116548

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In recent years, mass spectrometry (MS) is increasingly attracting interests for clinical applications, which also calls for technical innovations to make a transfer of MS from conventional analytical labo-ratories to clinics. The system design and analysis procedure should be friendly for novice users and appliable for on-site clinical diagnosis. In addition, the analysis result should be auto-interpreted and reported in formats much simpler than mass spectra. This motivates new ideas for developments in all the aspects of MS. In this review, we report recent advances of direct sampling ionization and miniature MS system, which have been developed targeting clinical and even point-of-care analysis. We also discuss the trend of the development and provide perspective on the technical challenges raised by diseases such as coronavirus SARS-CoV-2.(c) 2022 Elsevier B.V. All rights reserved.

引用

页数：9

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