The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer

被引：402

作者：

Chansky, Kari ^{[1
]}

Detterbeck, Frank C. ^{[2
]}

Nicholson, Andrew G. ^{[3
,4
]}

Rusch, Valerie W. ^{[5
]}

Vallieres, Eric ^{[6
]}

Groome, Patti ^{[7
]}

Kennedy, Catherine ^{[8
]}

Krasnik, Mark ^{[9
]}

Peake, Michael ^{[10
]}

Shemanski, Lynn ^{[1
]}

Bolejack, Vanessa ^{[1
]}

Crowley, John J. ^{[1
]}

Asamura, Hisao ^{[11
]}

Rami-Porta, Ramon ^{[12
,13
]}

机构：

[1] Canc Res & Biostat, Seattle, WA 98040 USA

[2] Yale Univ, Dept Surg, New Haven, CT USA

[3] Royal Brompton & Harefield Natl Hlth Serv Fdn Tru, Dept Histopathol, London, England

[4] Imperial Coll, London, England

[5] Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, New York, NY USA

[6] Swedish Canc Inst, Div Thorac Surg, Seattle, WA USA

[7] Queens Canc Res Inst, Kingston, ON, Canada

[8] Univ Sydney, Sydney, NSW, Australia

[9] Gentofte Univ Hosp, Copenhagen, Denmark

[10] Univ Leicester, Glenfield Hosp, Leicester, Leics, England

[11] Keio Sch Med, Div Thorac Surg, Tokyo, Japan

[12] Univ Barcelona, Hosp Univ Mutua Terrassa, Thorac Surg Serv, Barcelona, Spain

[13] Red Enfermedades Resp CIBERES Lung Canc Grp, Ctr Invest Biomed, Barcelona, Spain

来源：

JOURNAL OF THORACIC ONCOLOGY | 2017年 / 12卷 / 07期

关键词：

Lung cancer; Staging; National Cancer Database; AJCC; UICC; Validation; INTERNATIONAL ASSOCIATION; PROPOSALS;

D O I：

10.1016/j.jtho.2017.04.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Revisions to the TNM stage classifications for lung cancer, Informed by the international database (N = 94,708) of the International Association for the Study of Lung Cancer (IASLC) Staging and Prognostic Factors Committee, need external validation. The objective was to externally validate the revisions by using the National Cancer Data Base (NCDB) of the American College of Surgeons. Methods: Cases presenting from 2000 through 2012 were drawn from the NCDB and reclassified according to the eighth edition stage classification. Clinically and pathologically staged subsets of NSCLC were analyzed separately. The T, N, and overall TNM classifications were evaluated according to clinical, pathologic, and "best" stage (N = 780,294). Multivariate analyses were carried out to adjust for various confounding factors. A combined analysis of the NSCLC cases from both databases was performed to explore differences in overall survival prognosis between the two databases. Results: The databases differed in terms of key factors related to data source. Survival was greater in the IASLC database for all stage categories. However, the eighth edition TNM stage classification system demonstrated consistent ability to discriminate TNM categories and stage groups for clinical and pathologic stage. Conclusions: The IASLC revisions made for the eighth edition of lung cancer staging are validated by this analysis of the NCDB database by the ordering, statistical differences, and homogeneity within stage groups and by the consistency within analyses of specific cohorts. (C) 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

引用

页码：1109 / 1121

页数：13

共 11 条

[1]

American College of Surgeons, PART US FIL

[2] The International Association for the Study of Lung Cancer Lung Cancer Staging Project Proposals for the Revision of the N Descriptors in the Forthcoming 8th Edition of the TNM Classification for Lung Cancer [J].