Mass spectrometry of nucleotides and oligonucleotides

被引：7
作者：
Miketova, P [1 ]
Schram, KH [1 ]
机构：
[1] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA
来源：
MOLECULAR BIOTECHNOLOGY | 1997年 / 8卷 / 03期
关键词：
MALDI; ESI; mass spectrometry;
D O I：
10.1007/BF02760778
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in the use of mass spectrometry for the determination of the molecular weight and sequencing of oligonucleotides are disscussed. Matrix-assisted laser desorption (MALDI) and electrospray ionization (ESI) mass spectrometry have been shown to be especially important techniques for both molecular weight assignment and sequencing of oligonucleotides, and are the focus of this article which covers the literature through early 1996.
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收藏
页码：249 / 253
页数：5
相关论文
共 48 条
  • [1] ANTISENSE DNA OLIGONUCLEOTIDES .1. THE USE OF IONSPRAY TANDEM MASS-SPECTROMETRY FOR THE SEQUENCE VERIFICATION OF METHYLPHOSPHONATE OLIGODEOXYRIBONUCLEOTIDES
    BAKER, TR
    KEOUGH, T
    DOBSON, RLM
    RILEY, TA
    HASSELFIELD, JA
    HESSELBERTH, PE
    [J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1993, 7 (03) : 190 - 194
  • [2] BARRY JP, 1995, J MASS SPECTROM, V30, P933
  • [3] 5S RIBOSOMAL-RNA MODIFICATION IN THE HYPERTHERMOPHILIC ARCHAEA SULFOLOBUS-SOLFATARICUS AND PYRODICTIUM-OCCULTUM
    BRUENGER, E
    KOWALAK, JA
    KUCHINO, Y
    MCCLOSKEY, JA
    MIZUSHIMA, H
    STETTER, KO
    CRAIN, PF
    [J]. FASEB JOURNAL, 1993, 7 (01) : 196 - 200
  • [4] FOURIER-TRANSFORM MASS-SPECTROMETRY OF HIGH-MASS BIOMOLECULES
    BUCHANAN, MV
    HETTICH, RL
    [J]. ANALYTICAL CHEMISTRY, 1993, 65 (05) : A245 - &
  • [5] HIGH-RESOLUTION MATRIX-ASSISTED LASER-DESORPTION IONIZATION TIME-OF-FLIGHT ANALYSIS OF SINGLE-STRANDED-DNA OF 27 TO 68 NUCLEOTIDES IN LENGTH
    CHRISTIAN, NP
    COLBY, SM
    GIVER, E
    HOUSTON, CT
    ARNOLD, RJ
    ELLINGTON, AD
    REILLY, JP
    [J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1995, 9 (11) : 1061 - 1066
  • [6] ANALYSIS OF OLIGODEOXYNUCLEOTIDES BY NEGATIVE-ION MATRIX-ASSISTED LASER-DESORPTION MASS-SPECTROMETRY
    CURRIE, GJ
    YATES, JR
    [J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1993, 4 (12) : 955 - 963
  • [7] ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES
    FENN, JB
    MANN, M
    MENG, CK
    WONG, SF
    WHITEHOUSE, CM
    [J]. SCIENCE, 1989, 246 (4926) : 64 - 71
  • [8] BASIC MATRICES FOR THE MATRIX-ASSISTED LASER-DESORPTION IONIZATION MASS-SPECTROMETRY OF PROTEINS AND OLIGONUCLEOTIDES
    FITZGERALD, MC
    PARR, GR
    SMITH, LM
    [J]. ANALYTICAL CHEMISTRY, 1993, 65 (22) : 3204 - 3211
  • [9] THE ANALYSIS OF MOCK DNA-SEQUENCING REACTIONS USING MATRIX-ASSISTED LASER-DESORPTION IONIZATION MASS-SPECTROMETRY
    FITZGERALD, MC
    ZHU, L
    SMITH, LM
    [J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1993, 7 (10) : 895 - 897
  • [10] HATHAWAY GM, 1994, BIOTECHNIQUES, V17, P150
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