Electrospun nanobandage for hydrocortisone topical delivery as an antipsoriasis candidate

被引：16
作者：
Azandaryani, Abbas Hemati [1 ]
Derakhshandeh, Katayoun [2 ]
Arkan, Elham [1 ]
机构：
[1] Kermanshah Univ Med Sci, Nano Drug Delivery Res Ctr, Kermanshah, Iran
[2] Hamadan Univ Med Sci, Dept Pharmaceut, Fac Pharm, Hamadan, Iran
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2018年 / 67卷 / 11期
关键词：
Electrospinning; hydrocortisone; nanobandage; polyacrylonitrile; psoriasis; SOLID LIPID NANOPARTICLES; DRUG-DELIVERY; IN-VITRO; POLYACRYLONITRILE NANOFIBERS; POLYCAPROLACTONE NANOFIBERS; ANTIBACTERIAL PROPERTIES; CONTROLLED-RELEASE; ATOPIC-DERMATITIS; DAIRY-PRODUCTS; SYSTEM;
D O I：
10.1080/00914037.2017.1375493
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The aim of the present work was to introduce the novel and convenient nanoapproach for more effective control of psoriasis. In this study, the polyacrylonitrile (PAN)-based electrospun fiber-loaded hydrocortisone was prepared with a topical electrospinning process. The results showed that the nanofibers had a smooth surface with an average diameter of 288.62 +/- 46.42, 195.96 +/- 35.60, and 160.11 +/- 30.11 and the tensile stress of 1.74, 3.77, and 15.35MPa for PAN, PAN with 1 and 5% Tween 80, respectively. The amorphous dispersion of hydrocortisone in the nanobandage was proved by X-ray diffraction and differential scanning calorimetry study. The presence of Tween 80 increased drug released to completely 100% in investigated period with positive effect. The cytotoxicity study proved the noncytotoxicity of fibers against human umbilical vein endothelial cell line. [GRAPHICS] .
引用
收藏
页码：677 / 685
页数：9
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