Association between IVIM parameters and treatment response in locally advanced squamous cell cervical cancer treated by chemoradiotherapy

被引:25
作者
Perucho, Jose Angelo Udal [1 ]
Wang, Mandi [1 ]
Vardhanabhuti, Varut [1 ]
Tse, Ka Yu [2 ]
Chan, Karen Kar Loen [2 ]
Lee, Elaine Yuen Phin [1 ]
机构
[1] Univ Hong Kong, Queen Mary Hosp, Dept Diagnost Radiol, Room 406,Block K,Pok Fu Lam Rd, Hong Kong, Peoples R China
[2] Univ Hong Kong, Queen Mary Hosp, Dept Obstet & Gynaecol, Hong Kong, Peoples R China
关键词
Uterine cervical neoplasms; Chemoradiotherapy; Observer variation; Magnetic resonance imaging; Diffusion magnetic resonance imaging; INTRAVOXEL INCOHERENT MOTION; CONTRAST-ENHANCED MRI; DIFFUSION-WEIGHTED MRI; CONCURRENT CHEMORADIOTHERAPY; HISTOGRAM ANALYSIS; RADIATION-THERAPY; PROGNOSTIC VALUE; TUMOR RESPONSE; CARCINOMA; PERFUSION;
D O I
10.1007/s00330-021-07817-w
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective To examine the associations of intravoxel incoherent motion (IVIM) parameters with treatment response in cervical cancer following concurrent chemoradiotherapy (CCRT). Materials and methods Forty-five patients, median age of 58 years (range: 28-82), with pre-CCRT and post-CCRT MRI, were retrospectively analysed. The IVIM parameters pure diffusion coefficient (D) and perfusion fraction (f) were estimated using the full b-value distribution (BVD) as well as an optimised subsample BVD. Dice similarity coefficient (DSC) and intraclass correlation coefficient (ICC) were used to measure observer repeatability in tumour delineation at both time points. Treatment response was determined by the response evaluation criteria in solid tumour (RECIST) 1.1 between MRI examinations. Mann-Whitney U tests were used to test for significant differences in IVIM parameters between treatment response groups. Results Pre-CCRT tumour delineation repeatability was good (DSC = 0.81) while post-CCRT delineation repeatability was moderate (DSC = 0.67). Values of D and f had good repeatability at both time points (ICC > 0.80). Pre-CCRT f estimated using the full BVD and optimised subsample BVD were found to be significantly higher in patients with partial response compared to those with stable disease or disease progression (p = 0.01 and 95% CI = -0.02-0.00 for both cases). Conclusion Pre-CCRT f was associated with treatment response in cervical cancer with good observer repeatability. Similar discriminative ability was also observed in estimated pre-CCRT f from an optimised subsample BVD.
引用
收藏
页码:7845 / 7854
页数:10
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