The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents

被引:119
作者
Kowalski, Greg M. [1 ]
Bruce, Clinton R. [1 ]
机构
[1] Deakin Univ, Sch Exercise & Nutr Sci, Ctr Phys Activ & Nutr Res, Burwood, Vic 3125, Australia
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2014年 / 307卷 / 10期
基金
英国医学研究理事会;
关键词
type; 2; diabetes; glucose tolerance; gluconeogenesis; insulin resistance; endogenous glucose production; DEPENDENT DIABETES-MELLITUS; FREE FATTY-ACID; BROWN ADIPOSE-TISSUE; DUCHENNE-MUSCULAR-DYSTROPHY; HEPATIC INSULIN-RESISTANCE; RECEPTOR KNOCKOUT MICE; BETA-CELL DYSFUNCTION; DOSE-RESPONSE CURVES; MIXED MEAL; IN-VIVO;
D O I
10.1152/ajpendo.00165.2014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The incidence of insulin resistance and type 2 diabetes (T2D) is increasing at alarming rates. In the quest to understand the underlying causes of and to identify novel therapeutic targets to treat T2D, scientists have become increasingly reliant on the use of rodent models. Here, we provide a discussion on the regulation of rodent glucose metabolism, highlighting key differences and similarities that exist between rodents and humans. In addition, some of the issues and considerations associated with assessing glucose homeostasis and insulin action are outlined. We also discuss the role of the liver vs. skeletal muscle in regulating whole body glucose metabolism in rodents, emphasizing the importance of defective hepatic glucose metabolism in the development of impaired glucose tolerance, insulin resistance, and T2D.
引用
收藏
页码:E859 / E871
页数:13
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