Increased cytomegalovirus antibody level and DNA loads in early onset of pre-eclampsia

被引：23

作者：

Xie, Fang ^{[1
]}

Turvey, Stuart E. ^{[2
]}

Williams, Michelle A. ^{[3
]}

Mor, Gil ^{[4
]}

von Dadelszen, Peter ^{[1
]}

机构：

[1] Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC V6H 3N1, Canada

[2] Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1W5, Canada

[3] Univ Washington, Sch Publ Hlth & Community Med, Dept Epidemiol, Seattle, WA 98195 USA

[4] Yale Univ, Sch Med, Reprod Immunol Unit, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2010年 / 63卷 / 01期

基金：

加拿大健康研究院;

关键词：

Pre-eclampsia; Toll-like receptors signaling; TOLL-LIKE RECEPTORS; CHLAMYDIA-PNEUMONIAE; PRETERM BIRTH; HYPERTENSIVE DISORDERS; CARDIOVASCULAR-DISEASE; CAUCASIAN POPULATION; GENE POLYMORPHISMS; TROPHOBLAST CELLS; DENDRITIC CELLS; INNATE IMMUNITY;

D O I：

10.1111/j.1600-0897.2009.00745.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic inflammation and abnormal/poor placentation represent hallmarks of pre-eclampsia. Accumulating evidence suggests that infectious agents might increase the risk of pre-eclampsia; the innate immune defense mechanisms may interact with pro-inflammatory pathways, and contribute to the development of pre-eclampsia. The evidence for this has been supported by indirect epidemiologic and clinical studies, as well as by some direct support from experimental studies. Recent data directly implicate signaling by Toll-like receptors in the pathogenesis of pre-eclampsia, and establish a crucial link between pre-eclampsia and defense against both foreign pathogens and endogenously generated inflammatory ligands. Here, we review the rapid progress in this field, which has improved our understanding of the interplay between pathogen invasion, innate immune defense mechanisms, and pre-eclampsia.

引用

页码：7 / 16

页数：10

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