Disorders of Plasma Sodium - Causes, Consequences, and Correction

被引:338
作者
Sterns, Richard H. [1 ,2 ]
机构
[1] Univ Rochester, Sch Med & Dent, Rochester, NY USA
[2] Rochester Gen Hosp, Rochester, NY 14621 USA
关键词
OSMOTIC DEMYELINATION SYNDROME; INTENSIVE-CARE-UNIT; LONG-TERM TREATMENT; INAPPROPRIATE ANTIDIURESIS; INADVERTENT OVERCORRECTION; CHRONIC HYPONATREMIA; ORGANIC OSMOLYTES; HYPERTONIC SALINE; SERUM SODIUM; NA+ STORAGE;
D O I
10.1056/NEJMra1404489
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Human cells dwell in salt water. Their well-being depends on the ability of the body to regulate the salinity of extracellular fluids. By controlling water intake and excretion, the osmoregulatory system normally prevents the plasma sodium concentration from straying outside its normal range (135 to 142 mmol per liter). Failure of the system to regulate within this range exposes cells to hypotonic or hypertonic stress. This review considers the causes and consequences of an abnormal plasma sodium concentration and offers a framework for correcting it. © 2015 Massachusetts Medical Society.
引用
收藏
页码:55 / 65
页数:11
相关论文
共 77 条
  • [1] Overview and introduction: The blood-brain barrier in health and disease
    Abbott, N. Joan
    Friedman, Alon
    [J]. EPILEPSIA, 2012, 53 : 1 - 6
  • [2] Primary care -: Hypernatremia
    Adrogué, HJ
    Madias, NE
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (20) : 1493 - 1499
  • [3] The Challenge of Hyponatremia
    Adrogue, Horacio J.
    Madias, Nicolaos E.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (07): : 1140 - 1148
  • [4] Severe Hypernatremia Correction Rate and Mortality in Hospitalized Patients
    Alshayeb, Hala M.
    Showkat, Arif
    Babar, Fatima
    Mangold, Therese
    Wall, Barry M.
    [J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2011, 341 (05) : 356 - 360
  • [5] Neuroendocrine control of body fluid metabolism
    Antunes-Rodrigues, J
    De Castro, M
    Elias, LLK
    Valença, MM
    McCann, SM
    [J]. PHYSIOLOGICAL REVIEWS, 2004, 84 (01) : 169 - 208
  • [6] A systematic review of the ability of urine concentration to distinguish antipsychotic- from psychosis-induced hyponatremia
    Atsariyasing, Wanlop
    Goldman, Morris B.
    [J]. PSYCHIATRY RESEARCH, 2014, 217 (03) : 129 - 133
  • [7] Correlation of Plasma Copeptin and Vasopressin Concentrations in Hypo-, Iso-, and Hyperosmolar States
    Balanescu, Sandrina
    Kopp, Peter
    Gaskill, Mary Beth
    Morgenthaler, Nils G.
    Schindler, Christian
    Rutishauser, Jonas
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (04) : 1046 - 1052
  • [8] Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats
    Barsony, Julia
    Manigrasso, Michaele B.
    Xu, Qin
    Tam, Helen
    Verbalis, Joseph G.
    [J]. AGE, 2013, 35 (02) : 271 - 288
  • [9] Undercorrection of hypernatremia is frequent and associated with mortality
    Bataille, Stanislas
    Baralla, Camille
    Torro, Dominique
    Buffat, Christophe
    Berland, Yvon
    Alazia, Marc
    Loundou, Anderson
    Michelet, Pierre
    Vacher-Coponat, Henri
    [J]. BMC NEPHROLOGY, 2014, 15
  • [10] Berl T, 2008, J AM SOC NEPHROL, V19, P1076, DOI 10.1681/ASN.2007091042