Synthesis of the C-13 side chain precursors of the 9-dihydrotaxane analogue ABT-271

被引：7

作者：

Leanna, MR ^{[1
]}

DeMattei, JA ^{[1
]}

Li, WK ^{[1
]}

Nichols, PJ ^{[1
]}

Rasmussen, M ^{[1
]}

Morton, HE ^{[1
]}

机构：

[1] Abbott Labs, Div Pharmaceut Prod, N Chicago, IL 60064 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 23期

关键词：

D O I：

10.1021/ol006508o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] N-Boc-L-Leucinol was converted to two C-13 side chain precursors of the 9-dihydrotaxane analogue ABT-271. The trans-oxazolidine acid 4 and the cis-Boc-lactam 2b were prepared in 44% and 40% overall yield, respectively, and with excellent (>98%) stereochemical purity.

引用

页码：3627 / 3630

页数：4

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