An overview of recent progress in siderophore-antibiotic conjugates

被引：45

作者：

Kong, Huimin ^{[3
]}

Cheng, Weiyan ^{[1
,2
]}

Wei, Han ^{[1
,2
]}

Yuan, Yongliang ^{[1
,2
]}

Yang, Zhiheng ^{[1
,2
]}

Zhang, Xiaojian ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Precis Clin Pharm, Zhengzhou 450052, Henan, Peoples R China

[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Pediat, Zhengzhou 450052, Henan, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 182卷

基金：

中国国家自然科学基金;

关键词：

Siderophore; Antibiotic; Trojan horse; Sideromycin; Siderophore-antibiotic conjugates; SELECTIVE SIDEROMYCIN ANTIBIOTICS; IN-VITRO CHARACTERIZATION; ANTIBACTERIAL ACTIVITY; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; ESCHERICHIA-COLI; OUTER-MEMBRANE; IRON UPTAKE; ENTEROBACTIN; DELIVERY;

D O I：

10.1016/j.ejmech.2019.111615

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Multi-drug resistant infections caused by Gram-negative bacteria have become one of the most important reasons for the failure of clinical anti-infective treatment. Siderophore-antibiotic conjugates, which were designed based on a "Trojan horse" strategy wherein features enabled active uptake to bypass the Gram-negative cell wall, have been expected to be a weapon for anti-infective treatment in the clinic. Herein, we review antibiotic drug design strategies based on mimics of nature siderophores reported in recent years, we also focus our attention on the relationship between the type of linker and the corresponding antibacterial activity. (C) 2019 Elsevier Masson SAS. All rights reserved.

引用

页数：16

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