New insights into the roles of antiapoptotic members of the Bcl-2 family in melanoma progression and therapy

被引：16

作者：

Trisciuoglio, Daniela ^{[1
,2
]}

Del Bufalo, Donatella ^{[1
]}

机构：

[1] IRCCS Regina Elena Natl Canc Inst, Preclin Models & New Therapeut Agents Unit, Via Elio Chianesi 53, Rome, Italy

[2] CNR, Inst Mol Biol & Pathol, Via Apuli 4, I-00185 Rome, Italy

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 05期

关键词：

CHEMOSENSITIZES HUMAN-MELANOMA; TUMOR PROGRESSION; BH4; DOMAIN; ANTISENSE OLIGONUCLEOTIDE; APOPTOSIS REGULATORS; CONFERS RESISTANCE; MALIGNANT-MELANOMA; INDUCE APOPTOSIS; CYCLIN D1; EXPRESSION;

D O I：

10.1016/j.drudis.2021.01.027

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prosurvival and antiapoptotic B cell lymphoma-2 (Bcl-2) family proteins are often overexpressed in cutaneous melanoma, one of the most aggressive types of human cancer. They are also implicated in resistance to therapy and participate in melanoma progression by regulating various processes, including cell proliferation, migration, invasion, and crosstalk with the tumor microenvironment. In this review, we summarize recent findings related to prosurvival members of the Bcl-2 family beyond their canonical functions in the apoptotic pathway, mainly focusing on their potential roles as diagnostic and prognostic biomarkers in cutaneous melanoma. We also provide an overview of different approaches used to inhibit Bcl-2 proteins in preclinical and clinical studies, which are mainly based on the inhibition of protein expression or the disruption of their antiapoptotic functions.

引用

页码：1126 / 1135

页数：10

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