Cell proliferation measured by MIB1 and timing of surgery for breast cancer

被引：22

作者：

Cooper, LS ^{[1
]}

Gillett, CE ^{[1
]}

Smith, P ^{[1
]}

Fentiman, IS ^{[1
]}

Barnes, DM ^{[1
]}

机构：

[1] Guys Hosp, Imperial Canc Res Fund, Clin Oncol Unit, London SE1 9RT, England

来源：

BRITISH JOURNAL OF CANCER | 1998年 / 77卷 / 09期

关键词：

proliferative activity; MIB1; breast cancer; menstrual cycle; timing of surgery;

D O I：

10.1038/bjc.1998.247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated the use of the antibody MIB1 as a proliferative and prognostic marker in breast cancer and whether changes in proliferative activity could account for differences in prognosis of premenopausal women operated on during different phases of the menstrual cycle. MIB1 expression was strongly correlated with S-phase fraction and histological grade. There was no difference in MIB1 scores between different phases of the menstrual cycle. Both MIB1 score and timing of surgery correlated significantly with duration of survival, while the two together were even stronger predictors of overall survival. Women with slowly proliferating tumours surgically removed in the luteal phase had a very good prognosis, whereas women with rapidly proliferating tumours excised at other times of the cycle had a worse prognosis.

引用

页码：1502 / 1507

页数：6

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