Palladium-Catalyzed Allyl-Allyl Reductive Coupling of Allylamines or Allylic Alcohols with H2 as Sole Reductant

被引：18

作者：

Zhou, Xibing ^{[1
,2
]}

Zhang, Guoying ^{[3
]}

Huang, Renbin ^{[1
,2
]}

Huang, Hanmin ^{[1
,2
,3
,4
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[3] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

[4] Chinese Acad Sci, Ctr Excellence Mol Synth, Hefei 230026, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 02期

基金：

中国国家自然科学基金;

关键词：

CHIRAL DIPHOSPHINE LIGANDS; ALKYL-HALIDES; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; ARYL BROMIDES; COMPLEXES; HYDROGENOLYSIS; HYDROGENATION; ALDEHYDES; ELIMINATION;

D O I：

10.1021/acs.orglett.0c03865

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic carbon-carbon bond formation building on reductive coupling is a powerful method for the preparation of organic compounds. The identification of environmentally benign reductants is key for establishing an efficient reductive coupling reaction. Herein an efficient strategy enabling H-2 as the sole reductant for the palladium-catalyzed allyl-allyl reductive coupling reaction is described. A wide range of allylamines and allylic alcohols as well as allylic ethers proceed smoothly to deliver the C-C coupling products under 1 atm of H-2. Kinetic studies suggested that the dinuclear palladium species was involved in the catalytic cycle.

引用

页码：365 / 369

页数：5

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