Appreciating force and shape - the rise of mechanotransduction in cell biology

被引：599

作者：

Iskratsch, Thomas ^{[1
]}

Wolfenson, Haguy ^{[1
]}

Sheetz, Michael P. ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[2] Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2014年 / 15卷 / 12期

关键词：

FOCAL ADHESIONS; EXTRACELLULAR-MATRIX; INTERFERENCE-REFLECTION; MECHANICAL TENSION; TRACTION FORCES; DYNAMIC REORIENTATION; SUBSTRATE RIGIDITY; ALPHA-ACTININ; STRESS FIBERS; INTEGRIN;

D O I：

10.1038/nrm3903

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility - for example, during cell matrix adhesion development - through the signalling process of mechanotransduction.

引用

页码：825 / 833

页数：9

共 122 条

[1] LOCOMOTION OF FIBROBLASTS IN CULTURE .4. ELECTRON MICROSCOPY OF LEADING LAMELLA [J].

ABERCROM.M ;

HEAYSMAN, JE ;

PEGRUM, SM .

EXPERIMENTAL CELL RESEARCH, 1971, 67 (02) :359-&

[2]

[Anonymous], 1917, on Growth and Form

[3] A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors [J].

Aragona, Mariaceleste ;

Panciera, Tito ;

Manfrin, Andrea ;

Giulitti, Stefano ;

Michielin, Federica ;

Elvassore, Nicola ;

Dupont, Sirio ;

Piccolo, Stefano .

CELL, 2013, 154 (05) :1047-1059

[4] Transient Frictional Slip between Integrin and the ECM in Focal Adhesions under Myosin II Tension [J].

Aratyn-Schaus, Yvonne ;

Gardel, Margaret L. .

CURRENT BIOLOGY, 2010, 20 (13) :1145-1153

[5] Src kinase activation by direct interaction with the integrin β cytoplasmic domain [J].

Arias-Salgado, EG ;

Lizano, S ;

Sarkar, S ;

Brugge, JS ;

Ginsberg, MH ;

Shattil, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13298-13302

[6] Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL [J].

Baarlink, Christian ;

Wang, Haicui ;

Grosse, Robert .

SCIENCE, 2013, 340 (6134) :864-867

[7] Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates [J].

Balaban, NQ ;

Schwarz, US ;

Riveline, D ;

Goichberg, P ;

Tzur, G ;

Sabanay, I ;

Mahalu, D ;

Safran, S ;

Bershadsky, A ;

Addadi, L ;

Geiger, B .

NATURE CELL BIOLOGY, 2001, 3 (05) :466-472

[8] Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells [J].

Beil, M ;

Micoulet, A ;

von Wichert, G ;

Paschke, S ;

Walther, P ;

Omary, MB ;

Van Veldhoven, PP ;

Gern, U ;

Wolff-Hieber, E ;

Eggermann, J ;

Waltenberger, J ;

Adler, G ;

Spatz, J ;

Seufferlein, T .

NATURE CELL BIOLOGY, 2003, 5 (09) :803-811

[9] The integrin β tail is required and sufficient to regulate adhesion signaling to Rac1 [J].

Berrier, AL ;

Martinez, R ;

Bokoch, GM ;

LaFlamme, SE .

JOURNAL OF CELL SCIENCE, 2002, 115 (22) :4285-4291

[10] Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions [J].

Brown, Ashley C. ;

Fiore, Vincent F. ;

Sulchek, Todd A. ;

Barker, Thomas H. .

JOURNAL OF PATHOLOGY, 2013, 229 (01) :25-35

← 1 2 3 4 5 6 7 8 9 10 →