Catalytic asymmetric Darzens condensation under phase-transfer-catalyzed conditions

被引：81

作者：

Arai, S ^{[1
]}

Shioiri, T ^{[1
]}

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 467, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(98)00081-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic asymmetric Darzens condensation promoted by the quaternary ammonium salt (PTC A) derived from cinchonine as a phase-transfer catalyst is described. Treatment of phenacyl chloride with various aldehydes under mild reaction conditions afforded the corresponding desired product in good yield with good to moderate enantiomeric excess. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2145 / 2148

页数：4

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