Graphene oxide incorporated collagen-fibrin biofilm as a wound dressing material

被引：58

作者：

Deepachitra, R. ^{[1
]}

Ramnath, V. ^{[1
]}

Sastry, T. P. ^{[1
]}

机构：

[1] Cent Leather Res Inst, Bioprod Lab, Madras 600020, Tamil Nadu, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 107期

关键词：

IN-VIVO; DRUG-DELIVERY; GELATIN COMPOSITES; CHROME SHAVINGS; PROTEIN; SKIN; CYTOTOXICITY; MATRIX; SCALE; GRAFT;

D O I：

10.1039/c4ra10150b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Functionalized graphene oxide offers many advantages as a biomaterial in various biomedical applications. In the present study, graphene oxide (GO) was incorporated in the collagen-fibrin composite film (CFGO) and used as wound dressing material in both in vitro and in vivo studies. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using NIH 3T3 cells revealed that CFGO film is biocompatible. CFGO was also used as a wound dressing material on the experimental wounds of rats. Histopathological, biochemical and hematology studies have shown that the CFGO treated wounds healed faster than control and CF treated wounds. Based on the results, CFGO can be used as a wound dressing material in small and large animals.

引用

页码：62717 / 62727

页数：11

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