Biocatalytic Process Design and Reaction Engineering

被引:16
作者
Wohlgemuth, R. [1 ]
机构
[1] Sigma Aldrich, Merck Grp, Ind Str 25, CH-9470 Buchs, Switzerland
关键词
molecular economy; retrosynthetic analysis; route selection; biocatalytic asymmetric synthesis; biocatalysts; biocatalytic process assembly; biocatalytic process prototyping; reaction engineering; process intensification; product recovery; BAEYER-VILLIGER OXIDATION; ANALYTICAL TECHNOLOGY TOOLS; ORGANIC-SYNTHESIS; GLYCEROL DEHYDROGENASE; INDUSTRY PERSPECTIVES; L-GLYCERALDEHYDE; EFFICIENT; TRANSFORMATIONS; PHOSPHORYLATION; CHEMISTRY;
D O I
10.15255/CABEQ.2016.1029
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Biocatalytic processes occurring in nature provide a wealth of inspiration for manufacturing processes with high molecular economy. The molecular and engineering aspects of bioprocesses converting available raw materials into valuable products are therefore of much industrial interest. Modular reaction platforms and straightforward working paths, from the fundamental understanding of biocatalytic systems in nature to the design and reaction engineering of novel biocatalytic processes, have been important for shortening development times. Building on broadly applicable reaction platforms and tools for designing biocatalytic processes and their reaction engineering are key success factors. Process integration and intensification aspects are illustrated with biocatalytic processes to numerous small-molecular weight compounds, which have been prepared by novel and highly selective routes, for applications in the life sciences and biomedical sciences.
引用
收藏
页码:131 / 138
页数:8
相关论文
共 68 条
[21]   Microbial transformations 59: First kilogram scale asymmetric microbial Baeyer-Villiger oxidation with optimized productivity using a resin-based in situ SFPR strategy [J].
Hilker, I ;
Wohlgemuth, R ;
Alphand, V ;
Furstoss, R .
BIOTECHNOLOGY AND BIOENGINEERING, 2005, 92 (06) :702-710
[22]   On the influence of oxygen and cell concentration in an SFPR whole cell biocatalytic Baeyer-Villiger oxidation process [J].
Hilker, I ;
Baldwin, C ;
Alphand, V ;
Furstoss, R ;
Woodley, J ;
Wohlgemuth, R .
BIOTECHNOLOGY AND BIOENGINEERING, 2006, 93 (06) :1138-1144
[23]   Enzyme-mediated oxidations for the chemist [J].
Hollmann, Frank ;
Arends, Isabel W. C. E. ;
Buehler, Katja ;
Schallmey, Anett ;
Buehler, Bruno .
GREEN CHEMISTRY, 2011, 13 (02) :226-265
[24]  
Lee JW, 2012, NAT CHEM BIOL, V8, P536, DOI [10.1038/NCHEMBIO.970, 10.1038/nchembio.970]
[25]   Exploration of New Chemical Reactivities for Sustainable Molecular Transformations [J].
Li, Chao-Jun .
CHEM, 2016, 1 (03) :423-437
[26]  
Liese A., 2006, IND BIOTRANSFORMATIO, V2nd
[27]  
Lipshutz B. H., ACS SUSTAINABLE CHEM
[28]   Development of a chemoenzymatic manufacturing process for pregabalin [J].
Martinez, Carlos A. ;
Hu, Shanghui ;
Dumond, Yves ;
Tao, Junhua ;
Kelleher, Patrick ;
Tully, Liam .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2008, 12 (03) :392-398
[29]   One-step synthesis of 2-keto-3-deoxy-D-gluconate by biocatalytic dehydration of D-gluconate [J].
Matsubara, Kohei ;
Koehling, Rudi ;
Schoenenberger, Bernhard ;
Kouril, Theresa ;
Esser, Dominik ;
Braesen, Christopher ;
Siebers, Bettina ;
Wohlgemuth, Roland .
JOURNAL OF BIOTECHNOLOGY, 2014, 191 :69-77
[30]   Biocatalytic asymmetric phosphorylation of mevalonate [J].
Matsumi, R. ;
Hellriegel, C. ;
Schoenenberger, B. ;
Milesi, T. ;
van der Oost, J. ;
Wohlgemuth, R. .
RSC ADVANCES, 2014, 4 (25) :12989-12994