Producing GM-CSF: a unique T helper subset?

被引：26

作者：

Herndler-Brandstetter, Dietmar ^{[1
]}

Flavell, Richard A. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

CELL RESEARCH | 2014年 / 24卷 / 12期

关键词：

CELLS; MICE;

D O I：

10.1038/cr.2014.155

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

GM-CSF-producing helper T cells have previously been identified to serve a nonredundant function in the initiation of autoimmune inflammation. An article by Sheng et al. recently published by Cell Research now suggests that the differentiation program of GM-CSF-producing cells from naive CD4(+) T cells is distinct from that of Th1 and Th17 cells, and is regulated by the IL-7-STAT5 axis.

引用

页码：1379 / 1380

页数：2

共 9 条

[1] RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation [J].

Codarri, Laura ;

Gyuelveszi, Gabor ;

Tosevski, Vinko ;

Hesske, Lysann ;

Fontana, Adriano ;

Magnenat, Laurent ;

Suter, Tobias ;

Becher, Burkhard .

NATURE IMMUNOLOGY, 2011, 12 (06) :560-U248

[2] The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF [J].

El-Behi, Mohamed ;

Ciric, Bogoljub ;

Dai, Hong ;

Yan, Yaping ;

Cullimore, Melissa ;

Safavi, Farinaz ;

Zhang, Guang-Xian ;

Dittel, Bonnie N. ;

Rostami, Abdolmohamad .

NATURE IMMUNOLOGY, 2011, 12 (06) :568-U241

[3] Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation [J].

Laurence, Arian ;

Tato, Cristina M. ;

Davidson, Todd S. ;

Kanno, Yuka ;

Chen, Zhi ;

Yao, Zhengju ;

Blank, Rebecca B. ;

Meylan, Francoise ;

Siegel, Richard ;

Hennighausen, Lothar ;

Shevach, Ethan M. ;

O'Shea, John J. .

IMMUNITY, 2007, 26 (03) :371-381

[4] Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function [J].

Lee, Li-Fen ;

Logronio, Kathryn ;

Tu, Guang Huan ;

Zhai, Wenwu ;

Ni, Irene ;

Mei, Li ;

Dilley, Jeanette ;

Yu, Jessica ;

Rajpal, Arvind ;

Brown, Colleen ;

Appah, Charles ;

Chin, Sherman Michael ;

Han, Bora ;

Affolter, Timothy ;

Lin, John C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (31) :12674-12679

[5] CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice:: implications for the nonredundant function of IL-2 [J].

Malek, TR ;

Yu, AX ;

Vincek, V ;

Scibelli, P ;

Kong, L .

IMMUNITY, 2002, 17 (02) :167-178

[6] IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells [J].

Noster, Rebecca ;

Riedel, Rene ;

Mashreghi, Mir-Farzin ;

Radbruch, Helena ;

Harms, Lutz ;

Haftmann, Claudia ;

Chang, Hyun-Dong ;

Radbruch, Andreas ;

Zielinski, Christina E. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (241)

[7] Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells [J].

O'Shea, John J. ;

Paul, William E. .

SCIENCE, 2010, 327 (5969) :1098-1102

[8]

Ribeiro Daniel, 2013, Adv Biol Regul, V53, P211, DOI 10.1016/j.jbior.2012.10.005

[9] STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation [J].

Sheng, Wanqiang ;

Yang, Fan ;

Zhou, Yi ;

Yang, Henry ;

Low, Pey Yng ;

Kemeny, David Michael ;

Tan, Patrick ;

Moh, Akira ;

Kaplan, Mark H. ;

Zhang, Yongliang ;

Fu, Xin-Yuan .

CELL RESEARCH, 2014, 24 (12) :1387-1402

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