IRE1: A role in upregulation of ER degradation

被引：16
|
作者：
Hampton, RY [1 ]
机构：
[1] Univ Calif San Diego, Sect Cell & Dev Biol, Div Biol Sci, San Diego, CA 92103 USA
来源：
DEVELOPMENTAL CELL | 2003年 / 4卷 / 02期
关键词：
D O I：
10.1016/S1534-5807(03)00032-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The unfolded protein response entered the mechanistic realm with the discovery of IRE1 as the key signal transducer in yeast. Although also found in mammals, it appeared to function in assisting the work of other players. The featured studies indicate a separate role for IRE1, and highlight the flexibility that bigger eukaryotes possess in this critical pathway.
引用
收藏
页码：144 / 146
页数：3
相关论文
共 50 条
  • [31] The role of IRE1α in photoreceptor homeostasis and retinal degeneration
    Massoudi, Dawiyat
    Kuo, Yien-Ming
    Olivier, Alina
    Wiqas, Amen
    Oakes, Scott
    Papa, Feroz
    Gould, Douglas B.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (07)
  • [32] Role of IRE1α in podocyte proteostasis and mitochondrial health
    Navarro-Betancourt, Jose R.
    Papillon, Joan
    Guillemette, Julie
    Iwawaki, Takao
    Chung, Chen-Fang
    Cybulsky, Andrey, V
    CELL DEATH DISCOVERY, 2020, 6 (01)
  • [33] IRE1α maintains HSC stemness under ER-stress
    Marina Scheller-Wendorff
    Carsten Müller-Tidow
    Nature Cell Biology, 2019, 21 : 297 - 298
  • [34] ROLE OF THE ER STRESS TRANSDUCER IRE1 BETA IN AIRWAY INFLAMMATION-INDUCED MUCIN PRODUCTION
    Martino, M. B.
    Ehre, C.
    O'Neal, W. K.
    Ribeiro, C. P.
    PEDIATRIC PULMONOLOGY, 2009, : 259 - 259
  • [35] IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation
    Sun, Shengyi
    Shi, Guojun
    Sha, Haibo
    Ji, Yewei
    Han, Xuemei
    Shu, Xin
    Ma, Hongming
    Inoue, Takamasa
    Gao, Beixue
    Kim, Hana
    Bu, Pengcheng
    Guber, Robert D.
    Shen, Xiling
    Lee, Ann-Hwee
    Iwawaki, Takao
    Paton, Adrienne W.
    Paton, James C.
    Fang, Deyu
    Tsai, Billy
    Yates, John R., III
    Wu, Haoquan
    Kersten, Sander
    Long, Qiaoming
    Duhamel, Gerald E.
    Simpson, Kenneth W.
    Qi, Ling
    NATURE CELL BIOLOGY, 2015, 17 (12) : 1546 - 1555
  • [36] Clustering of IRE1α in the mammalian ER membrane is independent of its enzymatic activities
    Ricci, Daniela
    Marroco, Ilaria
    Vargas, Jade
    Eletto, Daniela
    Dibos, Miriam
    Boyle, Sarah
    Iwamoto, Yuichiro
    Argon, Yair
    FASEB JOURNAL, 2017, 31
  • [37] IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress
    Grey, Michael J.
    Cloots, Eva
    Simpson, Mariska S.
    LeDuc, Nicole
    Serebrenik, Yevgeniy, V
    De Luca, Heidi
    De Sutter, DeLphine
    Phi Luong
    Thiagarajah, Jay R.
    Paton, Adrienne W.
    Paton, James C.
    Seeliger, Markus A.
    Eyckerman, Sven
    Janssens, Sophie
    Lencer, Wayne, I
    JOURNAL OF CELL BIOLOGY, 2020, 219 (02):
  • [38] BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α
    Lisbona, Fernanda
    Rojas-Rivera, Diego
    Thielen, Peter
    Zamorano, Sebastian
    Todd, Derrick
    Martinon, Fabio
    Glavic, Alvaro
    Kress, Christina
    Lin, Jonathan H.
    Walter, Peter
    Reed, John C.
    Glimcher, Laurie H.
    Hetz, Claudio
    MOLECULAR CELL, 2009, 33 (06) : 679 - 691
  • [39] Clustering of IRE1α depends on sensing ER stress but not on its RNase activity
    Ricci, Daniela
    Marrocco, Ilaria
    Blumenthal, Daniel
    Dibos, Miriam
    Eletto, Daniela
    Vargas, Jade
    Boyle, Sarah
    Iwamoto, Yuichiro
    Chomistek, Steven
    Paton, James C.
    Paton, Adrienne W.
    Argon, Yair
    FASEB JOURNAL, 2019, 33 (09): : 9811 - 9827
  • [40] The ER stress transducer IRE1β is required for airway epithelial mucin production
    Martino, M. B.
    Jones, L.
    Brighton, B.
    Ehre, C.
    Abdulah, L.
    Davis, C. W.
    Ron, D.
    O'Neal, W. K.
    Ribeiro, C. M. P.
    MUCOSAL IMMUNOLOGY, 2013, 6 (03) : 639 - 654
12345