An Overview of Currently Available Antimalarials

被引：20

作者：

Gorobets, Nikolay Yu. ^{[1
]}

Sedash, Yuriy V. ^{[1
,2
]}

Singh, Brajendra K. ^{[3
]}

Poonam ^{[4
]}

Rathi, Brijesh ^{[5
,6
]}

机构：

[1] Natl Acad Sci Ukraine, Statate Sci Inst Inst Single Crystals, Dept Chem Heterocycl Cpds, Nauky Ave 60, UA-61001 Kharkov, Ukraine

[2] Zaporizhzhia State Med Univ, Dept Biochem & Lab Diagnost, Mayakovsky Ave 26, UA-69035 Zaporizhzhia, Ukraine

[3] Univ Delhi, Bioorgan Res Lab, Dept Chem, Delhi 110007, India

[4] Univ Delhi, Miranda House, Delhi 110007, India

[5] Univ Delhi, Hansraj Coll, Delhi 110007, India

[6] MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2017年 / 17卷 / 19期

关键词：

Malaria; Antimalarial drugs; Drug resistance; Mechanism of action; Antimalarial therapy; Plasmodium; PLASMODIUM-FALCIPARUM MALARIA; NO ROBUST EVIDENCE; ARTEMETHER-LUMEFANTRINE; DIHYDROARTEMISININ-PIPERAQUINE; UNCOMPLICATED MALARIA; CHLORPROGUANIL-DAPSONE; ATOVAQUONE-PROGUANIL; ARTEMISININ RESISTANCE; RANDOMIZED-TRIAL; DRUG DEVELOPMENT;

D O I：

10.2174/1568026617666170130123520

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: Despite the substantial progress over the time, malaria remains a major public health concern and causing hundreds of thousands of deaths. Resistance to the available antimalarial therapy increases threat to the global public health. Objective: Overview of currently available antimalarials. Method: Literary survey. Results: The summarized data about different types of antimalarial therapies and their efficiency and modes of action. Conclusion: Despite the seemingly large number of the drugs currently available for malaria treatment, this arsenal is limited due to the narrow variation of their mechanism of action.

引用

页码：2143 / 2157

页数：15

共 148 条

[1] Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination [J].

Abdul-Ghani, Rashad ;

Beier, John C. .

PARASITOLOGY RESEARCH, 2014, 113 (10) :3535-3546

[2] Safety and Immunogenicity of RTS,S/AS02D Malaria Vaccine in Infants [J].

Abdulla, Salim ;

Oberholzer, Rolf ;

Juma, Omar ;

Kubhoja, Sulende ;

Machera, Francisca ;

Membi, Christopher ;

Omari, Said ;

Urassa, Alwisa ;

Mshinda, Hassan ;

Jumanne, Ajuza ;

Salim, Nahya ;

Shomari, Mwanjaa ;

Aebi, Thomas ;

Schellenberg, David M. ;

Carter, Terrell ;

Villafana, Tonya ;

Demoitie, Marie-Ange ;

Dubois, Marie-Claude ;

Leach, Amanda ;

Lievens, Marc ;

Vekemans, Johan ;

Cohen, Joe ;

Ballou, W. Ripley ;

Tanner, Marcel .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (24) :2533-2544

[3]

Aminake M N., 2013, Microbial pathogens and strategies for combating them: science, technology and education, P269

[4]

[Anonymous], 2014, The Business Standard

[5]

[Anonymous], 2014, World Malaria Report

[6]

Anu Gopalakrishnan Anu Gopalakrishnan, 2014, International Journal of PharmTech Research, V6, P1354

[7] Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials [J].

Aponte, John J. ;

Schellenberg, David ;

Egan, Andrea ;

Breckenridge, Alasdair ;

Carneiro, Ilona ;

Critchley, Julia ;

Danquah, Ina ;

Dodoo, Alexander ;

Kobbe, Robin ;

Lell, Bertrand ;

May, Juergen ;

Premji, Zul ;

Sanz, Sergi ;

Sevene, Esperanza ;

Soulaymani-Becheikh, Rachida ;

Winstanley, Peter ;

Adjei, Samuel ;

Anemana, Sylvester ;

Chandramohan, Daniel ;

Issifou, Saadou ;

Mockenhaupt, Frank ;

Owusu-Agyei, Seth ;

Greenwood, Brian ;

Grobusch, Martin P. ;

Kremsner, Peter G. ;

Macete, Eusebio ;

Mshinda, Hassan ;

Newman, Robert D. ;

Slutsker, Laurence ;

Tanner, Marcel ;

Alonso, Pedro ;

Menendez, Clara .

LANCET, 2009, 374 (9700) :1533-1542

[8] The path of malaria vaccine development: challenges and perspectives [J].

Arama, C. ;

Troye-Blomberg, M. .

JOURNAL OF INTERNAL MEDICINE, 2014, 275 (05) :456-466

[9] A molecular marker of artemisinin-resistant Plasmodium falciparum malaria [J].

Ariey, Frederic ;

Witkowski, Benoit ;

Amaratunga, Chanaki ;

Beghain, Johann ;

Langlois, Anne-Claire ;

Khim, Nimol ;

Kim, Saorin ;

Duru, Valentine ;

Bouchier, Christiane ;

Ma, Laurence ;

Lim, Pharath ;

Leang, Rithea ;

Duong, Socheat ;

Sreng, Sokunthea ;

Suon, Seila ;

Chuor, Char Meng ;

Bout, Denis Mey ;

Menard, Sandie ;

Rogers, William O. ;

Genton, Blaise ;

Fandeur, Thierry ;

Miotto, Olivo ;

Ringwald, Pascal ;

Le Bras, Jacques ;

Berry, Antoine ;

Barale, Jean-Christophe ;

Fairhurst, Rick M. ;

Benoit-Vical, Franoise ;

Mercereau-Puijalon, Odile ;

Menard, Didier .

NATURE, 2014, 505 (7481) :50-+

[10]

Ashley Elizabeth, 2006, Travel Med Infect Dis, V4, P159, DOI 10.1016/j.tmaid.2005.06.009

← 1 2 3 4 5 6 7 8 9 10 →