Effective PDT/PTT dual-modal phototherapeutic killing of bacteria by using poly(N-phenylglycine) nanoparticles

被引：5

作者：

Ghayyem, Sena ^{[1
,2
]}

Barras, Alexandre ^{[1
]}

Faridbod, Farnoush ^{[2
]}

Szunerits, Sabine ^{[1
]}

Boukherroub, Rabah ^{[1
]}

机构：

[1] Univ Lille, Univ Polytech Hauts De France, CNRS, UMR 8520,Cent Lille,IEMN, F-59000 Lille, France

[2] Univ Tehran, Sch Chem, Coll Sci, Analyt Chem Dept, Tehran 1417935840, Iran

来源：

MICROCHIMICA ACTA | 2022年 / 189卷 / 04期

关键词：

Polymer-based nanomaterials; Antibacterial therapy; Escherichia coli; Staphylococcus aureus; Biofilm; ESCHERICHIA-COLI; PHOTOTHERMAL ABLATION; NANOMATERIALS; INACTIVATION; THERAPY; LIGHT; NANOSTRUCTURES; NANOCOMPOSITES; EFFICIENCY; WATER;

D O I：

10.1007/s00604-022-05181-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This study investigated, for the first time, the antimicrobial properties of polyethylene glycol-functionalized poly(N-phenylglycine) nanoparticles (PNPG-PEG NPs). PNPG-PEG NPs exhibit high extinction coefficient in the near-infrared (NIR) region; they can convert light energy into heat energy with high thermal transformation efficiency. Additionally, they can generate cytotoxic reactive oxygen species (ROS) upon light irradiation. Also, PNPG-PEG NPs are not cytotoxic. All these properties make them appropriate for combined dual-modal photothermal and photodynamic therapies. The antibacterial activity of PNPG-PEG NPs was assessed using Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) pathogenic strains. The results revealed that NIR light (810 nm) irradiation for 10 min could kill effectively the planktonic bacteria and destroy Escherichia coli and Staphylococcus aureus biofilms. The results demonstrated that PNPG-PEG NPs represent a very effective nanoplatform for killing of pathogenic bacteria.

引用

页数：11

共 40 条

[1] Enhancement of the Antibacterial Efficiency of Silver Nanoparticles against Gram-Positive and Gram-Negative Bacteria Using Blue Laser Light [J].