Coagulation Management in Trauma: Do We Need a Viscoelastic Hemostatic Assay?

被引:1
作者
Richards, Justin E. [1 ,2 ]
Fedeles, Benjamin T. [3 ]
机构
[1] Univ Maryland, Div Trauma Anesthesiol, R Adams Cowley Shock Trauma Ctr, Sch Med, 22 S Greene St, Baltimore, MD 77212 USA
[2] Univ Maryland, Div Crit Care Med, R Adams Cowley Shock Trauma Ctr, Sch Med, 22 S Greene St, Baltimore, MD 77212 USA
[3] Univ Cincinnati, Coll Med, Dept Anesthesiol Crit Care Med, Med Sci Bldg,Room 3502,Mail Locat 0531, Cincinnati, OH 45267 USA
关键词
Trauma; Hemorrhage; Bleeding; Coagulopathy; Viscoelastic testing; Fibrinogen; Platelets; Acute traumatic coagulopathy; Fibrinolysis; Tranexamic acid; Plasma; Conventional coagulation tests; Thromboelastography; Thromboelastometry; TRANEXAMIC ACID; INDUCED COAGULOPATHY; ROTATIONAL THROMBOELASTOMETRY; RAPID THROMBELASTOGRAPHY; FIBRINOLYSIS SHUTDOWN; MASSIVE TRANSFUSION; PREDICTS MORTALITY; EARLY AMPLITUDES; FIBRINOGEN; RESUSCITATION;
D O I
10.1007/s40140-022-00532-2
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Purpose of Review Coagulopathy is present in nearly 25% of severely injured patients and increases significantly with administration of massive transfusion of blood products. The cell-based model of hemostasis provides a background on which the current understanding of Acute Traumatic Coagulopathy (ATC) is managed. Recent Findings Viscoelastic Hemostatic Assays (VHAs) generate results that identify severely injured trauma patients at risk for large-volume blood transfusion, coagulation deficiencies, and increased mortality that are available more quickly than Conventional Coagulation Tests (CCTs). Viscoelastic-guided resuscitation during hemorrhage was recently described and demonstrated no difference in 24-h survival and free of massive transfusion. VHAs are potentially valuable in early detection of patients at risk for massive resuscitation and severe coagulopathy. This review will address the ACT, clinical data supporting VHA utilization in trauma patients, and limitations in scientific knowledge of viscoelastic testing.
引用
收藏
页码:277 / 285
页数:9
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