CYTOTOXIC ACTIVITY STUDIES OF SOME PLATINUM(II) COMPLEXES WITH 2-SUBSTITUTEDBENZIMIDAZOLE LIGANDS

被引：1
作者：
Ozcelik, Azime Berna [1 ]
Gumus, Fatma [1 ]
Kilic Suloglu, Aysun [2 ]
Selmanoglu, Guldeniz [2 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey
[2] Hacettepe Univ, Fac Sci, Dept Biol, TR-06800 Ankara, Turkey
来源：
REVUE ROUMAINE DE CHIMIE | 2019年 / 64卷 / 09期
关键词：
benzimidazole; platinum complexes; cytotoxic activity; HeLa cell line; MCF-7 cell line; ANTIMICROBIAL ACTIVITY; DNA INTERACTIONS; BENZIMIDAZOLE; DERIVATIVES; BINDING; SPECTRA; ACID;
D O I：
10.33224/rrch.2019.64.9.10
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present study, two Pt( II) complexes with 2-substitutedbenzimida-zole ligands were synthesized and evaluated for their in vitro cytotoxic activities on HeLa and MCF-7 cell lines. 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test results showed that complex 2 which was found to be the more active than carboplatin was the most cytotoxic active compound against the HeLa and MCF-7 cell lines among the tested compounds.
引用
收藏
页码：829 / 834
页数：6
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