CYTOTOXIC ACTIVITY STUDIES OF SOME PLATINUM(II) COMPLEXES WITH 2-SUBSTITUTEDBENZIMIDAZOLE LIGANDS

被引：1
作者：
Ozcelik, Azime Berna [1 ]
Gumus, Fatma [1 ]
Kilic Suloglu, Aysun [2 ]
Selmanoglu, Guldeniz [2 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey
[2] Hacettepe Univ, Fac Sci, Dept Biol, TR-06800 Ankara, Turkey
来源：
REVUE ROUMAINE DE CHIMIE | 2019年 / 64卷 / 09期
关键词：
benzimidazole; platinum complexes; cytotoxic activity; HeLa cell line; MCF-7 cell line; ANTIMICROBIAL ACTIVITY; DNA INTERACTIONS; BENZIMIDAZOLE; DERIVATIVES; BINDING; SPECTRA; ACID;
D O I：
10.33224/rrch.2019.64.9.10
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present study, two Pt( II) complexes with 2-substitutedbenzimida-zole ligands were synthesized and evaluated for their in vitro cytotoxic activities on HeLa and MCF-7 cell lines. 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) test results showed that complex 2 which was found to be the more active than carboplatin was the most cytotoxic active compound against the HeLa and MCF-7 cell lines among the tested compounds.
引用
收藏
页码：829 / 834
页数：6
相关论文
共 32 条
  • [1] Transition-Metal-Free O-, S-, and N-Arylation of Alcohols, Thiols, Amides, Amines, and Related Heterocycles
    Cano, Rafael
    Ramon, Diego J.
    Yus, Miguel
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2011, 76 (02) : 654 - 660
  • [2] Chaudhari B.N., 2012, International Journal of Pharmaceutical Chemistry, V2, P27
  • [3] Platinum-based drugs: past, present and future
    Dilruba, Shahana
    Kalayda, Ganna V.
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2016, 77 (06) : 1103 - 1124
  • [4] Eren G, 2011, FABAD J PHARM SCI, V36, P69
  • [5] In Vitro Cytotoxic Activities of Platinum(II) Complex with 1-Methyl-2-(3′-hydroxypropyl)benzimidazole and 2-(3′-Hydroxypropyl)benzimidazolium Hexa- and Tetrachloroplatinate Salts
    Eren, Gokcen
    Yilmaz, Sukran
    Gumus, Fatma
    [J]. LETTERS IN DRUG DESIGN & DISCOVERY, 2018, 15 (01) : 65 - 69
  • [6] Ersan S, 1997, ARZNEIMITTELFORSCH, V47, P410
  • [7] Garbutcheon B. J., 2017, EURO J INORG CHEM, V12, P1613
  • [8] Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(-) and S(+)-2-α,-hydroxybenzylbenzimidazole)2Cl2] complexes
    Gökçe, M
    Utku, S
    Gür, S
    Özkul, A
    Gümüs, F
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (02) : 135 - 141
  • [9] Studies on the synthesis, characterization, cytotoxic activities and plasmid DNA binding of platinum(II) complexes having 2-subsituted benzimidazole ligands
    Gozelle, Mahmut
    Suloglu, Aysun Kilic
    Selmanoglu, Guldeniz
    Ramazanoglu, Nagehan
    Acik, Leyla
    Gumus, Fatma
    [J]. POLYHEDRON, 2019, 161 : 298 - 308
  • [10] Synthesis, characterization and in vitro cytotoxic, mutagenic and antimicrobial activity of platinum(II) complexes with substituted benzimidazole ligands
    Gümüs, F
    Pamuk, I
    Özden, T
    Yildiz, S
    Diril, N
    Öksüzoglu, E
    Gür, S
    Özkul, A
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2003, 94 (03) : 255 - 262
1234