Design and synthesis of potential new apoptosis agents: hybrid compounds containing perillyl alcohol and new constrained retinoids

被引：17

作者：

Das, Bhaskar C. ^{[1
,2
]}

Mahalingam, Sakkarapalayam M. ^{[2
]}

Panda, Lipsa ^{[2
]}

Wang, Bo ^{[2
]}

Campbell, Philip D. ^{[2
]}

Evans, Todd ^{[3
]}

机构：

[1] Albert Einstein Coll Med, Dept Nucl Med, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[3] Cornell Univ, Weill Cornell Med Coll, Dept Surg, New York, NY 10021 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 11期

关键词：

ACID;

D O I：

10.1016/j.tetlet.2010.01.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N,N'-dicyclohexyl carbodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1462 / 1466

页数：5

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