Bundles of care for prevention of ventilator-associated pneumonia caused by carbapenem-resistant Klebsiella pneumoniae in the ICU

Objective: To investigate the treatment efficacy of bundles of care for the prevention of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Klebsiella pneumoniae in the intensive care unit (ICU). Methods: A total of 102 patients undergoing mechanical ventilation in the ICU of our hospital were randomly assigned into a research group (n=51, bundles of care) and a control group (n=51, routine care). The incidence of VAP, pathogenic bacteria in the sputum, outcome and medication compliance (Morisky medication adherence scale (MMAS) score) of patients as well as the hand hygiene rate of nurses were compared between the two groups. Results: The research group showed significantly shorter time of mechanical ventilation and ICU stay, lower incidence of VAP and less ICU hospitalization costs than the control group (all P<0.05). The detection rate of pathogenic bacteria in the research group was significantly lower than that in the control group (P<0.01). Both the MMAS score and the hand hygiene rate of nurses were higher in the research group than in the control group (both P<0.01). The mortality of the research group was significantly lower than that of the control group (P<0.05). Conclusion: Bundles of care for patients undergoing mechanical ventilation in ICU can greatly shorten the time of mechanical ventilation, reduce nosocomial infection, decrease the incidence of VAP and the mortality, and is conducive to improving the hand hygiene of nurses and the medication compliance of patients.