The impact of population-wide rapid antigen testing on SARS-CoV-2 prevalence in Slovakia

被引：129

作者：

Pavelka, Martin ^{[1
,2
,3
]}

Van-Zandvoort, Kevin ^{[4
,5
]}

Abbott, Sam ^{[4
,5
]}

Sherratt, Katharine ^{[4
,5
]}

Majdan, Marek ^{[6
]}

Jarcuska, Pavol ^{[7
]}

Krajci, Marek ^{[1
]}

Flasche, Stefan ^{[4
,5
]}

Funk, Sebastian ^{[4
,5
]}

机构：

[1] Slovak Minist Hlth, Bratislava, Slovakia

[2] Inst Hlth Anal, Bratislava, Slovakia

[3] London Sch Hyg & Trop Med, Dept Publ Hlth & Policy, London, England

[4] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England

[5] London Sch Hyg & Trop Med, Ctr Math Modelling Infect Dis, London, England

[6] Trnava Univ, Fac Hlth Sci & Social Work, Inst Global Hlth & Epidemiol, Trnava, Slovakia

[7] Pavol Jozef Safarik Univ, Fac Med, Kosice, Slovakia

来源：

SCIENCE | 2021年 / 372卷 / 6542期

基金：

英国惠康基金; 欧洲研究理事会; 英国生物技术与生命科学研究理事会; 欧盟地平线“2020”; 比尔及梅琳达.盖茨基金会;

关键词：

D O I：

10.1126/science.abf9648

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Slovakia conducted multiple rounds of population-wide rapid antigen testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2020, combined with a period of additional contact restrictions. Observed prevalence decreased by 58% (95% confidence interval: 57 to 58%) within 1 week in the 45 counties that were subject to two rounds of mass testing, an estimate that remained robust when adjusting for multiple potential confounders. Adjusting for epidemic growth of 4.4% (1.1 to 6.9%) per day preceding the mass testing campaign, the estimated decrease in prevalence compared with a scenario of unmitigated growth was 70% (67 to 73%). Modeling indicated that this decrease could not be explained solely by infection control measures but required the addition of the isolation and quarantine of household members of those testing positive.

引用

页码：635 / +

页数：36

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