The role of blood rheology in sickle cell disease

被引：146

作者：

Connes, Philippe ^{[1
,2
,3
,4
]}

Alexy, Tamas ^{[5
,6
]}

Detterich, Jon ^{[7
]}

Romana, Marc ^{[1
,2
]}

Hardy-Dessources, Marie-Dominique ^{[1
,2
]}

Ballas, Samir K. ^{[8
]}

机构：

[1] CHU Pointe A Pitre, Hop Ricou, Inserm UMR 1134, Pointe A Pitre 97157, Guadeloupe, France

[2] PRES Sorbonne Paris Cite, Lab Excellence GR Ex Red Cell Genesis Death, F-75015 Paris, France

[3] Inst Univ France, Paris, France

[4] Univ Lyon 1, Sect Vasc Biol & Red Blood Cell, Lab CRIS EA647, F-69100 Villeurbanne, France

[5] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA

[6] Atlanta VA Med Ctr, Cardiol Sect, Decatur, GA USA

[7] Childrens Hosp Los Angeles, Div Cardiol, Los Angeles, CA USA

[8] Thomas Jefferson Univ, Jefferson Med Coll, Cardeza Fdn Hematol Res, Dept Med, Philadelphia, PA 19107 USA

来源：

BLOOD REVIEWS | 2016年 / 30卷 / 02期

关键词：

Sickle cell disease; Blood viscosity; Red blood cell deformability; Red blood cell aggregation; Vaso-occlusive crises; OXIDE SYNTHASE ACTIVATION; ACUTE CHEST SYNDROME; NITRIC-OXIDE; ALPHA-THALASSEMIA; PULMONARY-HYPERTENSION; AGGREGATE STRENGTH; OXIDATIVE STRESS; ANEMIA PATIENTS; PAINFUL CRISIS; STEADY-STATE;

D O I：

10.1016/j.blre.2015.08.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies performed in the last decades have highlighted the need to better understand the contribution of the endothelium, vascular function, oxidative stress, inflammation, coagulation, hemolysis and vascular adhesion mechanisms to the pathophysiology of acute vaso-occlusive like events and chronic organ damages in sickle cell disease (SCD). Although SCD is a hemorheological disease, a few works focused on the contribution of blood viscosity, plasma viscosity, red blood cell deformability and aggregation in the pathophysiology of SCD. After a brief description of basic hemorheology, the present review focuses on the role of the hemorheological abnormalities in the causation of several SCD complications, mainly in sickle cell anemia and hemoglobin (Hb) SC disease. Several genetic and cellular modulators of blood rheology in SCD are discussed, as well as unresolved questions and perspectives. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：111 / 118

页数：8

共 110 条

[1] RHEOLOGICAL CHANGES IN THE PRODROMAL AND ESTABLISHED PHASES OF SICKLE-CELL VASOOCCLUSIVE CRISIS [J].