Effects of a neurodevelopmental genes based polygenic risk score for schizophrenia and single gene variants on brain structure in non-clinical subjects: A preliminary report

被引：6

作者：

Spalthoff, Robert ^{[1
]}

Degenhardt, Franziska ^{[4
,5
,6
]}

Awasthi, Swapnil ^{[9
]}

Heilmann-Heimbach, Stefanie ^{[4
,5
,6
]}

Besteher, Bianca ^{[1
]}

Gaser, Christian ^{[1
,2
]}

Ripke, Stephan ^{[7
,8
,9
]}

Noethen, Markus M. ^{[4
,5
,6
]}

Nenadic, Igor ^{[1
,3
]}

机构：

[1] Jena Univ Hosp, Dept Psychiat & Psychotherapy, Jena, Germany

[2] Jena Univ Hosp, Dept Neurol, Jena, Germany

[3] Phillips Univ Marburg, Dept Psychiat & Psychotherapy, Marburg Univ Hosp UKGM, Rudolf Bultmann Str 8, D-35039 Marburg, Germany

[4] Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany

[5] Univ Hosp Bonn, Bonn, Germany

[6] Univ Bonn, Life & Brain Ctr, Dept Genom, Bonn, Germany

[7] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA

[8] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA

[9] Charite, Dept Psychiat & Psychotherapy, D-10117 Berlin, Germany

来源：

SCHIZOPHRENIA RESEARCH | 2019年 / 212卷

关键词：

Schizophrenia; Voxel-based morphometry; Cortical thickness; Gyrification; Polygenic risk score; Neurodevelopment; VOLUME; HERITABILITY; ONSET; AGE;

D O I：

10.1016/j.schres.2019.07.061

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We tested whether a polygenic risk score integrating the effects of genes affecting neurodevelopment is associated to brain structural variation in healthy subjects. We acquired magnetic resonance imaging and genetic data of 167 healthy adults and computed a neurodevelopmental polygenic risk score (nPRS). We correlated the nPRS with local gyrification, cortical thickness and grey matter density and explored effects of single nucleotide polymorphisms included in the score. We did not find significant correlations of this nPRS with either measure. Individuals with the risk allele at rs11139497 show increases in cortical thickness (p < 0.05, FWE corrected) of the left superior temporal gyms. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：225 / 228

页数：4

共 19 条

[1] Heritability of Changes in Brain Volume Over Time in Twin Pairs Discordant for Schizophrenia [J].