Chromosome translocations: dangerous liaisons revisited

被引：186

作者：

Rowley, JD ^{[1
]}

机构：

[1] Univ Chicago, Med Ctr, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 03期

关键词：

D O I：

10.1038/35106108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although it has been clear for more than a century that the chromosomes in human tumour cells are often wildly abnormal, there has been controversy as to whether these changes are primary events or are merely secondary epiphenomena that reflect the genomic instability of these cells. The prevailing view for most of this period was that chromosome changes were secondary events. What happened to change this view?.

引用

页码：245 / 250

页数：6

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