Decreased regional homogeneity in insula and cerebellum: A resting-state fMRI study in patients with major depression and subjects at high risk for major depression

被引：222

作者：

Liu, Zhifen ^{[1
]}

Xu, Cheng ^{[2
]}

Xu, Yong ^{[1
]}

Wang, Yanfang ^{[1
]}

Zhao, Bing ^{[1
]}

Lv, Yating ^{[3
]}

Cao, Xiaohua ^{[1
]}

Zhang, Kerang ^{[1
]}

Du, Chongxi ^{[2
]}

机构：

[1] Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan 030001, Peoples R China

[2] Shanxi Prov Hosp, Dept Radiol, Taiyuan 030012, Peoples R China

[3] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2010年 / 182卷 / 03期

关键词：

Major depressive disorder; First-degree relative; Functional magnetic resonance imaging; Resting state; FUNCTIONAL MAGNETIC-RESONANCE; MOOD-REGULATING CIRCUIT; ANTERIOR CINGULATE CORTEX; ANTIDEPRESSANT TREATMENT; NEURAL RESPONSE; CONNECTIVITY; DISORDER; BRAIN; STIMULI; FACES;

D O I：

10.1016/j.pscychresns.2010.03.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Functional disconnectivity during the resting state has been observed in subjects with major depressive disorder (MDD), and in subjects at high genetic risk for major depression during task performance. It is hypothesized that functional impairments in certain brain areas are present in patients with MDD and in their first-degree relatives. To test this hypothesis, an analysis of regional homogeneity (ReHo) of the whole brain was performed on 45 subjects. Compared with the control group, subjects with MDD and those at high risk for MDD exhibited significantly decreased ReHo in the right insula and in the left cerebellum. These abnormalities may play an important role in the pathophysiology of depression. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：211 / 215

页数：5

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