The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer

被引：71
作者：
Kim, Jung-Hoon [1 ]
Song, Jaewhan [1 ]
Park, Kye Won [2 ]
机构：
[1] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biochem, Seoul 120749, South Korea
[2] Sungkyunkwan Univ, Coll Biotechnol & Biotechnol, Dept Food Sci & Biotechnol, Suwon 440746, Gyeonggi Do, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2015年 / 38卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
PPAR gamma; Obesity; Metabolism; Immunity; Cancer; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; TRANSCRIPTION FACTOR; LIGAND ACTIVATION; PROSTATE-CANCER; CARCINOMA CELLS; GENE-EXPRESSION; DENDRITIC CELLS; BETA-CATENIN; FAT;
D O I：
10.1007/s12272-015-0559-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The consumption of high-calorie foods combined with less physical exercise has increased the prevalence of obesity. Obesity is also associated with high blood pressure, atherosclerosis, insulin resistance, diabetes, impaired host defense, and the risk of some cancers. Because PPAR gamma is a central player that participates in various biological responses, including lipid metabolism, inflammation, and cell proliferation, further understanding of the lipid metabolic sensor PPAR gamma is necessary to reduce the incidence of metabolic diseases and cancer.
引用
收藏
页码：302 / 312
页数：11
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