Immunosuppressant prescription pattern and trend in kidney transplantation: A multicenter study in Korea

被引：16

作者：

Chang, Ji-Yeun ^{[1
]}

Yu, Jihyun ^{[1
]}

Chung, Byung Ha ^{[1
]}

Yang, Jaeseok ^{[2
]}

Kim, Sung-Joo ^{[3
]}

Kim, Chan-Duck ^{[4
]}

Lee, Sang-Ho ^{[5
]}

Lee, Jong Soo ^{[6
]}

Kim, Joong Kyung ^{[7
]}

Jung, Cheol Woong ^{[8
]}

Oh, Chang Kwon ^{[9
]}

Yang, Chul Woo ^{[1
]}

机构：

[1] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Nephrol, Seoul, South Korea

[2] Seoul Natl Univ Hosp, Transplantat Ctr, Seoul, South Korea

[3] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Surg, Seoul, South Korea

[4] Kyungpook Natl Univ Hosp, Dept Internal Med, Div Nephrol, Daegu, South Korea

[5] Kyung Hee Univ Hosp Gangdong, Dept Internal Med, Div Nephrol, Seoul, South Korea

[6] Ulsan Univ Hosp, Dept Internal Med, Div Nephrol, Ulsan, South Korea

[7] Bong Seng Mem Hosp, Dept Internal Med, Div Nephrol, Busan, South Korea

[8] Korea Univ, Anam Hosp, Dept Surg, Seoul, South Korea

[9] Ajou Univ Hosp, Dept Surg, Suwon, South Korea

来源：

PLOS ONE | 2017年 / 12卷 / 08期

关键词：

COATED MYCOPHENOLATE SODIUM; RENAL-TRANSPLANTATION; MOFETIL; RECIPIENTS; TACROLIMUS; EFFICACY; SYMPHONY; THERAPY; SAFETY;

D O I：

10.1371/journal.pone.0183826

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background The actual prescription pattern of immunosuppressive agents in kidney transplantation is unclear. Methods We investigated the pattern and trend of immunosuppressive treatment for kidney transplant patients in South Korea. A total of 636 patients at nine transplant centers were enrolled and followed for one year. We reviewed medical records and evaluated induction therapy, as well as the changing pattern and cause of maintenance therapy. Results Most patients (n = 621, 97.6%) received induction therapy often comprising basiliximab (n = 542, 85.2%). The triple therapy including calcineurin inhibitor, mycophenolic acid, and steroids was the major initial maintenance immunosuppression (n = 518, 81.4%), but its proportion decreased by 14% (81.4% to 67.5%) after 1 year. Almost 40% of patients changed immunosuppressive regimen during the 1-year follow-up, most often at an early period (60.2% within the first 4 months). The primary reason for the change was gastrointestinal discomfort (n = 113, 29.8%), followed by infection (112, 29.6%). The most common changing pattern was mycophenolic acid withdrawal (n = 155, 39.1%). Conclusion The initial immunosuppressive regimen is prone to change within the first year of kidney transplantation. Further studies are needed to evaluate the benefits and risks in patients who changed immunosuppressants.

引用

页数：14

共 19 条

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