SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

被引：244

作者：

Grifoni, Alba ^{[1
]}

Sidney, John ^{[1
]}

Vita, Randi ^{[1
]}

Peters, Bjoern ^{[1
,2
]}

Crotty, Shane ^{[1
,2
]}

Weiskopf, Daniela ^{[1
]}

Sette, Alessandro ^{[1
,2
]}

机构：

[1] La Jolla Inst Immunol LJI, Ctr Infect Dis & Vaccine Res, La Jolla, CA 92037 USA

[2] Univ Calif San Diego UCSD, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA 92037 USA

来源：

CELL HOST & MICROBE | 2021年 / 29卷 / 07期

关键词：

HLA CLASS-I; COMPREHENSIVE ANALYSIS; VIRUS; ANTIGEN; IMMUNODOMINANCE; BINDING; IMMUNOPREVALENCE; IDENTIFICATION; RECOGNITION; MUTATIONS;

D O I：

10.1016/j.chom.2021.05.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings. We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance. We also report additional analysis of SARS-CoV-2 human CD4 and CD8 T cell epitope data compiled from these studies, identifying 1,400 different reported SARS-CoV-2 epitopes and revealing discrete immunodominant regions of the virus and epitopes that are more prevalently recognized. This remarkable breadth of epitope repertoire has implications for vaccine design, cross-reactivity, and immune escape by SARS-CoV-2 variants.

引用

页码：1076 / 1092

页数：17

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