Multiple memory mechanisms? The long and the short of it

被引：6

作者：

Bannerman, David M. ^{[1
]}

Sprengel, Rolf ^{[2
]}

机构：

[1] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England

[2] Max Planck Inst Med Res, Dept Mol Neurobiol, Heidelberg, Germany

来源：

EMBO JOURNAL | 2010年 / 29卷 / 11期

基金：

英国惠康基金;

关键词：

SPATIAL MEMORY; SYNAPTIC PLASTICITY; MICE; POTENTIATION; DELETION; TERM;

D O I：

10.1038/emboj.2010.90

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synaptic plasticity is known to be intrinsically linked to cytoskeletal remodelling. In a new study published in this issue of The EMBO Journal, Rust et al have therefore generated and analysed a forebrain-specific mouse knockout of the actin-severing factor n-cofilin. Intriguingly, these mice exhibit a particular form of learning impairment-intact working memory but impaired spatial reference memory, correlating with a deficit in long-lasting long-term potentiation (LTP).

引用

页码：1790 / 1791

页数：2

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