Enantioselective syntheses of both enantiomers of cis-pyrrolidine 225H

被引：7
|
作者：
Shu, Hong [1 ]
Noble, April R. [1 ]
Zhang, Suhong [1 ]
Miao, Lei [1 ]
Trudell, Mark L. [1 ]
机构：
[1] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA
来源：
TETRAHEDRON | 2010年 / 66卷 / 25期
关键词：
Amphibian alkaloids; Ant venom alkaloids; Pyrrolidine; Enantioselective synthesis; 2,5-DISUBSTITUTED PYRROLIDINES; VENOM ALKALOIDS; STEREOSELECTIVE-SYNTHESIS; QUINOLIZIDINE ALKALOIDS; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; AMPHIBIAN SKIN; CHEMISTRY; ROUTE; FROGS;
D O I：
10.1016/j.tet.2010.04.037
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The efficient and expeditious syntheses of both enantiomers of the amphibian alkaloid cis-225H have been achieved. Utilizing a common cis-2,5-disubstituted pyrrolidine building block derived from (+)-2-tropinone, the enantioselective syntheses have established the absolute configuration of these alkaloids as (+)-(2R,5S) and (-)-(5S,2R). (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4428 / 4433
页数：6
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