Principles and applications of optogenetics in developmental biology

被引：85

作者：

Krueger, Daniel ^{[1
]}

Izquierdo, Emiliano ^{[1
]}

Viswanathan, Ranjith ^{[1
,2
]}

Hartmann, Jonas ^{[1
]}

Cartes, Cristina Pallares ^{[1
]}

De Renzis, Stefano ^{[1
]}

机构：

[1] EMBL, Dev Biol Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany

[2] Heidelberg Univ, Fac Biosci, D-69117 Heidelberg, Germany

来源：

DEVELOPMENT | 2019年 / 146卷 / 20期

关键词：

Embryonic development; Optogenetics; Signaling; Synthetic biology; Tissue morphogenesis; GENE-EXPRESSION SYSTEM; SPATIOTEMPORAL CONTROL; OPTICAL CONTROL; KINASE-ACTIVITY; REMOTE-CONTROL; CELL FATE; ACTIVATION; PHOTOSTIMULATION; TRANSCRIPTION; LOCALIZATION;

D O I：

10.1242/dev.175067

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The development of multicellular organisms is controlled by highly dynamic molecular and cellular processes organized in spatially restricted patterns. Recent advances in optogenetics are allowing protein function to be controlled with the precision of a pulse of laser light in vivo, providing a powerful new tool to perturb developmental processes at a wide range of spatiotemporal scales. In this Primer, we describe the most commonly used optogenetic tools, their application in developmental biology and in the nascent field of synthetic morphogenesis.

引用

页数：13

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