Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry

被引：11

作者：

Choi, Hyunsik ^{[1
]}

Kwon, Mina ^{[2
]}

Choi, Hye Eun ^{[2
]}

Hahn, Sei Kwang ^{[1
]}

Kim, Ki Su ^{[2
,3
,4
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, Dept Mat Sci & Engn, 77 Cheongam Ro, Pohang 790784, Gyeongbuk, South Korea

[2] Pusan Natl Univ, Sch Chem Engn, Coll Engn, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea

[3] Brigham & Womens Hosp, Ctr Nanomed, 45 Francis St, Boston, MA 02115 USA

[4] Harvard Med Sch, 45 Francis St, Boston, MA 02115 USA

来源：

MATERIALS | 2021年 / 14卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

hyaluronate; click chemistry; nanogel; noninvasive; drug delivery;

D O I：

10.3390/ma14061504

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically modified drugs. Here, HA nanogels were synthesized by crosslinking via "click" chemistry for noninvasive topical delivery of a model drug without chemical modification. The model-drug-encapsulating HA nanogels could be uptaken to the skin melanoma cells in vitro by HA-mediated endocytosis. In addition, histological analysis showed that HA nanogels could be topically delivered to the deep skin and tongue tissues through the noninvasive delivery routes. Taken together, HA nanogels could be effectively used for the noninvasive topical delivery of various therapeutic drugs.

引用

页数：9

共 28 条

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