Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives

被引：15

作者：

Zhou, Wei-Ming ^{[1
,2
]}

He, Rong-Rong ^{[1
]}

Ye, Jian-Tao ^{[1
]}

Zhang, Na ^{[1
]}

Liu, De-Yu ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Guangdong Food & Drug Vocat Coll, Guangzhou 510520, Guangdong, Peoples R China

来源：

MOLECULES | 2010年 / 15卷 / 04期

关键词：

ampelopsin; 5-fluorouracil; anticancer activity; IN-VITRO; CYTOTOXICITY;

D O I：

10.3390/molecules15042114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, H-1-NMR, C-13-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.

引用

页码：2114 / 2123

页数：10

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