Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives

被引：15

作者：

Zhou, Wei-Ming ^{[1
,2
]}

He, Rong-Rong ^{[1
]}

Ye, Jian-Tao ^{[1
]}

Zhang, Na ^{[1
]}

Liu, De-Yu ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Guangdong Food & Drug Vocat Coll, Guangzhou 510520, Guangdong, Peoples R China

来源：

MOLECULES | 2010年 / 15卷 / 04期

关键词：

ampelopsin; 5-fluorouracil; anticancer activity; IN-VITRO; CYTOTOXICITY;

D O I：

10.3390/molecules15042114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, H-1-NMR, C-13-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.

引用

页码：2114 / 2123

页数：10

共 30 条

[1] Total synthesis of 3,3′,4-tri-O-methylellagic acid from gallic acid [J].

Alam, Ashraful ;

Tsuboi, Sadao .

TETRAHEDRON, 2007, 63 (42) :10454-10465

[2]

[Anonymous], CHIN J CANC

[3] Ester-based precursors to increase the bioavailability of quercetin [J].

Biasutto, Lucia ;

Marotta, Ester ;

De Marchi, Umberto ;

Zoratti, Mario ;

Paradisi, Cristina .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (02) :241-253

[4]

BOUNOUS G, 1978, INT J CLIN PHARM BI, V16, P265

[5] Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates [J].

Cai, TWB ;

Tang, XP ;

Nagorski, J ;

Brauschweiger, PG ;

Wang, PG .

BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (23) :4971-4975

[6]

Contino C, 1999, MACROMOL CHEM PHYSIC, V200, P1351, DOI 10.1002/(SICI)1521-3935(19990601)200:6<1351::AID-MACP1351>3.0.CO

[7]

2-O

[8] Isolation and identification of an anti-tumor component from leaves of Impatiens balsamina [J].

Ding, Zhi-Shan ;

Jiang, Fu-Sheng ;

Chen, Ni-Pi ;

Lv, Gui-Yuan ;

Zhu, Cheng-Gang .

MOLECULES, 2008, 13 (02) :220-229

[9] Synthesis and evaluation of new 5-fluorouracil antitumor cell differentiating derivatives [J].

Domínguez, JF ;

Marchal, JA ;

Correa, A ;

Carrillo, E ;

Boulaiz, H ;

Aránega, A ;

Gallo, MA ;

Espinosa, A .

BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (03) :315-323

[10] 5-Fluorouracil trapping in poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels:: in vitro drug delivery studies [J].

García, O ;

Blanco, MD ;

Martín, JA ;

Teijón, JM .

EUROPEAN POLYMER JOURNAL, 2000, 36 (01) :111-122

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