Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation

被引：13

作者：

Debache, Abdelmadjid ^{[1
]}

Ghalem, Wassima ^{[1
]}

Boulcina, Raouf ^{[1
]}

Belfaitah, Ali ^{[1
]}

Rhouati, Salah ^{[1
]}

Carboni, Bertrand ^{[2
]}

机构：

[1] Univ Mentouri Constantine, Fac Sci Exactes, Dept Chim, Lab Prod Nat Origine Vegetal & Synth Organ, Constantine 25000, Algeria

[2] Univ Rennes 1, CNRS, UMR Sci Chim Rennes 6226, F-35042 Rennes, France

来源：

LETTERS IN ORGANIC CHEMISTRY | 2010年 / 7卷 / 04期

关键词：

Triethylamine; Bronsted bases; multicomponent reaction; 3,4-dihydropyrimidin-2(1H)-ones/thiones; Biginelli reaction; one-pot condensation; ONE-POT SYNTHESIS; IMPROVED PROTOCOL CONDITIONS; CALCIUM-CHANNEL BLOCKERS; REUSABLE CATALYST; DIHYDROPYRIMIDINE SYNTHESIS; MULTICOMPONENT REACTIONS; FLUOROUS SYNTHESIS; ACID; CHEMISTRY; 3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES;

D O I：

10.2174/157017810791130595

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and simple protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by a one-pot three-component cyclocondensation reaction of an aromatic aldehyde, beta-ketoester, and urea or thiourea under solvent-free conditions using triethylamine (Et(3)N) as catalyst for the Biginelli reaction.

引用

页码：272 / 276

页数：5

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