A Water-Soluble Bis(thiosemicarbazone) Ligand. A Sensitive Probe and Metal Buffer for Zinc

被引：28

作者：

Buncic, Gojko

Donnelly, Paul S. ^{[1
]}

Paterson, Brett M.

White, Jonathan M.

Zimmermann, Matthias

Xiao, Zhiguang

Wedd, Anthony G.

机构：

[1] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

来源：

INORGANIC CHEMISTRY | 2010年 / 49卷 / 07期

基金：

澳大利亚研究理事会;

关键词：

ION SENSING PROPERTIES; FLUORESCENCE; COMPLEXES; CHEMOSENSORS; BINDING; CU(II); COPPER;

D O I：

10.1021/ic902370a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first member of a water-soluble family of bis(thiosemicarbazone) ligands is reported. It forms a 1:1 complex with Zn-II that absorbs intensely in the visible region (lambda(max) = 414 nm; epsilon = 1.8(4) x 10(4) M-1 cm(-1); pH 7.3). Its affinity for Zn-II (K-D = 5.9(3) x 10(-9) M at pH 7.3) was determined by competition with ligand ethylene glycol O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid. Its potential application as a chromophoric probe was demonstrated by estimation of the Zn-II binding affinities of the soluble metal-binding domains of two plant metal-transporting proteins.

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页码：3071 / 3073

页数：3

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