The Bohlmann-Rahtz route to functionalised pyridine scaffolds and their use in library synthesis

被引：44
作者：
Bashford, KE
Burton, MB
Cameron, S
Cooper, AL
Hogg, RD
Kane, PD
MacManus, DA
Matrunola, CA
Moody, CJ
Robertson, AAB
Warne, MR
机构：
[1] Tripos Receptor Res Ltd, Bude EX23 8LY, Cornwall, England
[2] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 08期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/S0040-4039(03)00034-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Bohlmann-Rahtz reaction has been used to prepare 2,3,6-trisubstituted pyridines suitable for use in library synthesis. The synthesis of piperidine substituted nicotinic acid derivative 9 has been optimised and carried out on a large scale to give ca. 500 g of scaffold which was used in the generation of the pyridine library 11. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：1627 / 1629
页数：3
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