Gastric Protective Activities of Sea Cucumber Fucoidans with Different Molecular Weight and Chain Conformations: A Structure-Activity Relationship Investigation

被引:58
作者
Xu, Xiaoqi [1 ,2 ]
Chang, Yaoguang [1 ]
Xue, Changhu [1 ]
Wang, Jingfeng [1 ]
Shen, Jingjing [1 ]
机构
[1] Ocean Univ China, Coll Food Sci & Engn, 5 Yushan Rd, Qingdao 266003, Peoples R China
[2] Nanjing Tech Univ, Coll Food Sci & Light Ind, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
fucoidan; ethanol-induced gastric ulcer; molecular weight; chain conformation; sea cucumber; structure-activity relationship; GASTROPROTECTIVE ACTIVITY; REPEATING UNIT; MUCOSA; ULCER; FLEXIBILITY; VISCOSITY; DISEASE; LUNG; VIVO;
D O I
10.1021/acs.jafc.8b01497
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
A variety of bioactivities has been established for fucoidan extracted from sea cucumber, whereas its structure activity relationships have been seldom investigated. In this study, sea cucumber (Thelenota ananas) fucoidans with different molecular weights were prepared with enzymatic degradation. The chain stiffness and molecular size decreased with the decreasing of molecular weight. Fucoidans with molecular weight of 1380.0, 828.7, and 483.0 kDa exhibited random coil conformations, while fucoidan molecular weight of 215.0 kDa existed as sphere in solution. All examined fucoidans could effectively prevent the ethanol-induced gastric ulcer, of which mechanism involved antioxidation and anti-inflammation. Within the range of the study, the performance of fucoidans adopted random coil conformations declined with the decreasing of molecular weight, and the performance recovered when the chain conformation transited from coil to sphere, indicating the subtle influences of molecular weight and chain conformation on the gastric protective activity of sea cucumber fucoidan.
引用
收藏
页码:8615 / 8622
页数:8
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