A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia

被引：4

作者：

Zhang, Y. ^{[1
]}

Zhang, Q. ^{[1
,2
]}

Che, E. X. ^{[1
]}

Xia, D. D. ^{[1
]}

Liu, Y. C. ^{[1
]}

Li, D. ^{[3
]}

Zhang, Z. D. ^{[3
]}

Wang, S. L. ^{[1
]}

机构：

[1] Shen Yang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang Pharmaceut Univ, 103 Wenhua Rd, Shenyang 110016, Peoples R China

[2] Jiangsu Hengrui Med Co Ltd, Lianyungang 222000, Peoples R China

[3] Chinese Acad Sci, Int Ctr Mat Phys, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China

来源：

MATERIALS TECHNOLOGY | 2015年 / 30卷 / B4期

关键词：

Magnetic particles; Mesoporous silicon; Magnetic heat; Synchronised therapy; NANOPARTICLES; CORE;

D O I：

10.1179/17535557B15Y.000000010

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A magnetic mesoporous silicon (MMS) composite with magnetic particles as the core and mesoporous as the shell was prepared. The MMS composite was characterised by means of transmission electron microscopy (TEM), X-ray diffraction (XRD), and nitrogen adsorption. The MMS composite with the pore-size of 2 and 200 nm in diameter had a good application prospect in the magnetic-induction hyperthermia and drug delivery. The composite function of magnetic-induction hyperthermia was measured by a high-frequency-induction heating machine with the frequency 608 kHz and the field amplitude 6.4 kA m(-1). The magnetic mesoporous composite took about 7 min to heat up 45 degrees C with the average heating rate of 2.25 degrees C min(-1). The function of loading doxorubicin (DOX) hydrochloride was measured at 488 nm on a UV-Vis spectrophotometry, and the loading efficiency with 20.1% was achieved for the DOX hydrochloride being possibly loaded into the mesoporous. This result put MMS a way of the synchronised therapy of hyperthermia and magnetic target drug delivery.

引用

页码：B211 / B215

页数：5

共 16 条

[1] Paclitaxel/gelatin coated magnetic mesoporous silica nanoparticles: Preparation and antitumor efficacy in vivo [J].