Fabrication of Microneedles Using Two Photon Polymerization for Transdermal Delivery of Nanomaterials

被引：47
作者：
Doraiswamy, Anand [1 ]
Ovsianikov, Aleksandr [2 ]
Gittard, Shaun D. [1 ]
Monteiro-Riviere, Nancy A. [1 ,3 ]
Crombez, Rene [4 ]
Montalvo, Eva [4 ]
Shen, Weidian [4 ]
Chichkov, Boris N. [2 ]
Narayan, Roger J. [1 ]
机构：
[1] N Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27695 USA
[2] Laser Zentrum Hannover, Dept Nanotechnol, D-30419 Hannover, Germany
[3] N Carolina State Univ, Ctr Chem Toxicol Res & Pharmacokinet, Raleigh, NC 27606 USA
[4] Eastern Michigan Univ, Surface Sci & Nanotribol Lab, Ypsilanti, MI 48197 USA
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2010年 / 10卷 / 10期
关键词：
Microneedle; Transdermal Drug Delivery; Rapid Prototyping; Nanomaterials; Human Epidermal Keratinocytes; QUANTUM DOTS; INSULIN DELIVERY; INSERTION FORCE; NANOPARTICLES; SKIN; NANOCRYSTALS; ARRAY;
D O I：
10.1166/jnn.2010.2636
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microneedle devices for transdermal delivery of nanoscale pharmacologic agents were fabricated out of organically-modified ceramic (Ormocer(R)) materials using two photon polymerization. Out-of-plane hollow microneedle arrays with various aspect ratios were fabricated using this rapid prototyping process. Human epidermal keratinocyte (HEK) viability on Ormocer(R) surfaces fabricated using two photon polymerization was similar to that on control surfaces. Nanoindentation studies were performed to determine hardness and Young's modulus values for Ormocer(R) materials. Microneedles were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration. Our results suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents.
引用
收藏
页码：6305 / 6312
页数：8
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