Beyond immunohistochemistry and immunocytochemistry: a current perspective on galectin-3 and thyroid cancer

被引:22
作者
Li, Jennifer [1 ,2 ]
Vasilyeva, Elizaveta [1 ,2 ]
Wiseman, Sam M. [1 ,2 ]
机构
[1] St Pauls Hosp, Dept Surg, Vancouver, BC, Canada
[2] Univ British Columbia, Vancouver, BC, Canada
关键词
Thyroid cancer; galectin-3; FNA; targeted therapy; thyroid cancer diagnostic imaging; FINE-NEEDLE-ASPIRATION; SERUM GALECTIN-3; IN-VIVO; DOWN-REGULATION; EXPRESSION; CARCINOMA; INHIBITION; MARKER; DIAGNOSIS; INVASION;
D O I
10.1080/14737140.2019.1693270
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction: Thyroid nodules are very common in the general population, most are benign, and do not require any intervention. However, often a challenge exists in discriminating benign thyroid nodules from cancer, without performing a biopsy or operation. Galectin-3 is a beta-galactoside binding protein that is involved in diverse biological processes and has been found to have increased expression in many human cancer types including thyroid cancer. As a result, recent studies have investigated its utility as a serum biomarker for thyroid cancer, as well as a novel target for in vivo molecular imaging of cancer. Additionally, given its role in tumorigenesis and cancer progression, galectin-3 targeting is currently under investigation for its potential utility as treatment for thyroid cancer. Areas covered: Recent studies of galectin-3 as a serum marker for thyroid cancer diagnosis, and in the preclinical setting as a target for cancer imaging and therapy. Expert opinion: Even though current studies evaluating galectin-3 as a serum marker and target for cancer imaging and therapy are promising, further research is required before it can be adopted into routine clinical use.
引用
收藏
页码:1017 / 1027
页数:11
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