A new efficient method for the preparation of intermediate aromatic ketones by Friedel-Crafts acylation

被引：21

作者：

Jin, Xiaojun ^{[1
]}

Wang, Ailing ^{[1
,3
]}

Cao, Hongyu ^{[2
,3
]}

Zhang, Shujia ^{[1
]}

Wang, Lihao ^{[1
]}

Zheng, Xueliang ^{[1
]}

Zheng, Xuefang ^{[2
,3
]}

机构：

[1] Dalian Univ, Dept Chem Engn, Dalian 116622, Peoples R China

[2] Dalian Univ, Coll Bioengn, Dalian 116622, Peoples R China

[3] Dalian Univ, Liaoning Key Lab Bioorgan Chem, Dalian 116622, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2018年 / 44卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Aromatic ketones; Friedel-Crafts; Acylation; Deep eutectic solvent; DEEP EUTECTIC SOLVENTS; IONIC LIQUIDS; CARBOXYLIC-ACIDS; TRIFLATE; CATALYST; TOLUENE; ARENES;

D O I：

10.1007/s11164-018-3437-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As the most important method to prepare pharmaceutical and chemical intermediate aromatic ketones, Friedel-Crafts (F-C) acylation is used to seek a novel catalytic system which is imminently consistent with the concept of green chemistry. In this study, six deep eutectic solvents (DES) were synthesized for the Friedel-Crafts acylation reaction as a catalytic solvent. Among the six DES, choline chloride-zinc chloride ([ChCl][ZnCl2](2)) proved to be the most competent candidate of electron-rich arenes with acylation reagent. It got the highest yield when 1.0 equivalent of [ChCl][ZnCl2](2) used with acyl halides at 70 degrees C. Recycled DES was reused directly without any extra process. After five cycles, the catalytic activity did not decrease significantly (80-85%). Finally, according to experimental validation, the possible mechanism of this reaction was considered. [GRAPHICS] .

引用

页码：5521 / 5530

页数：10

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